overview

The hallmark of my research career is the development of novel antibodies and applying them toward the development of new immuno-biotechnological tools. My lab has developed an antibody discovery platform in chickens that goes from in silico sequence to epitope-specific chicken IgG (IgY) in less than 3 weeks based on in vivo CD40-targeted immunogen delivery.

Research projects include the study of the immune response in the chicken, especially the function of CD40-positive antigen presenting cells (such as the dendritic cells) in activating the humoral immune response and the development of chicken egg yolk antibodies, monoclonal antibodies and recombinant antibodies for diagnostic, prophylactic and therapeutic purposes. a Dr. Berghman was the recipient of the 2016 Zoetis Fundamental Science Award.

education and training
selected publications
Academic Articles136
  • Zhao, D., Farnell, M. B., Kogut, M. H., Genovese, K. J., Chapkin, R. S., Davidson, L. A., Berghman, L. R., & Farnell, Y. Z. (2022). From crypts to enteroids: establishment and characterization of avian intestinal organoids. Poultry Science. 101(3), 101642-101642.
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  • Al-Ogaili, A. S., Liyanage, R., Lay, J. O., Jiang, T., Vuong, C. N., Agrawal, S., ... Kwon, Y. M. (2020). DNA aptamer-based rolling circle amplification product as a novel immunological adjuvant.. Sci Rep. 10(1), 22282.
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  • Vuong, C. N., Kuttappan, V. A., Faulkner, O. B., Berghman, L. R., Wolfenden, A. D., Tellez-Isaias, G., ... Bielke, L. R. (2020). Comparison of oil emulsion, mannosylated chitosan, and Bacillus vector adjuvants for vaccination against influenza in chickens. Journal of Applied Poultry Research. 29(3), 653-664.
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  • Chockalingam, K., Peng, Z., Vuong, C. N., Berghman, L. R., & Chen, Z. (2020). Golden Gate assembly with a bi-directional promoter (GBid): A simple, scalable method for phage display Fab library creation.. Sci Rep. 10(1), 2888.
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  • Vuong, C. N., Chou, W., & Berghman, L. R. (2019). CD205-positive, Sepharose-induced peritoneal exudate cells: a new resource for DC research in the chicken.. Vet Res Commun. 43(2), 115-122.
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Chapters1
  • A., D., & R., L. (2012). Immunoaffinity Chromatography: A Review. Affinity Chromatography. 91-106. InTech.
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Conference Papers11
  • Jianhan Lin, .., Lum, J., Ronghui Wang, .., Tung, S., Hargis, B., Yanbin Li, .., Huaguang Lu, .., & Berghman, L. (2010). A portable impedance biosensor instrument for rapid detection of avian influenza virus. 2010 IEEE Sensors, 2010 Ninth IEEE Sensors Conference (SENSORS 2010). 1558-1563.
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  • Hargis, B. M., Layton, S. L., Kapczynski, D. R., Cole, K., Cox, M. M., Kwon, Y. M., ... Bottje, W. J. (2008). Development and evaluation of a potential universal Salmonella-vectored avian influenza vaccine. POULTRY SCIENCE. 87, 2-3.
  • Khatiwara, A., Layton, S. L., Tellez, G., Berghman, L. R., Bottje, W. J., Hargis, B. M., & Kwon, Y. M. (2008). Development and initial evaluation of a candidate Clostridium perfringens a toxin-based necrotic enteritis vaccine utilizing recombinant Salmonella as a vaccine vector. POULTRY SCIENCE. 87, 19-19.
  • Cole, K., Layton, S. L., Cox, M. M., Kwon, Y. M., Berghman, L. R., Bottje, W. G., & Hargis, B. M. (2007). Evaluation of a novel recombinant salmonella vaccine vector for avian influenza. POULTRY SCIENCE. 86, 585-586.
  • Abi-Ghanem, D., Ameiss, K., Caldwell, D. J., & Berghman, L. R. (2005). Optimization of an invasion assay for Eimeria tenella sporozoites. POULTRY SCIENCE. 84, 28-28.
Repository Documents / Preprints1
  • Wells, K., He, K., Pandey, A., Cabello, A., Zhang, D., Yang, J., ... de Figueiredo, P. (2021). Diverse pathogens activate the host RIDD pathway to subvert BLOS1-directed immune defense.
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patents
Patents11
chaired theses and dissertations
Email
berghman@tamu.edu
First Name
Luc
Last Name
Berghman
mailing address
Texas A&M University; Poultry Science; 2472 TAMU
College Station, TX 77843-2472
USA