Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus. Human cytomegalovirus (HCMV or Human herpesvirus 5) is a large DNA virus (>235 kb) that belongs to the Betaherpesvirinae genus of the Herpesviridae family. Primary HCMV infection in immunocompetent individuals is usually benign but establishes a lifelong latent state.
- Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States), Postdoctoral Training 1999
- University of Glasgow - (Glasgow, United Kingdom), Postdoctoral Training 1997
- Ph.D. in Virology, University of Glasgow - (Glasgow, United Kingdom) 1994
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2020). Neutralizing antibodies to gB based CMV vaccine requires full length antigen but reduced virus neutralization on non-fibroblast cells limits vaccine efficacy in the guinea pig model. VACCINE. 38(10), 2340-2349.
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2019). Inclusion of the Viral Pentamer Complex in a Vaccine Design Greatly Improves Protection against Congenital Cytomegalovirus in the Guinea Pig Model. J Virol. 93(22),
- Coleman, S., Choi, K. Y., & McGregor, A. (2017). Cytomegalovirus UL128 homolog mutants that form a pentameric complex produce virus with impaired epithelial and trophoblast cell tropism and altered pathogenicity in the guinea pig. VIROLOGY. 509, 205-221.
- Hornig, J., Choi, K. Y., & McGregor, A. (2017). The essential role of guinea pig cytomegalovirus (GPCMV) TEl and IE2 homologs in viral replication and IE1-mediated ND10 targeting. VIROLOGY. 504, 122-140.
- Coleman, S., Choi, K. Y., Root, M., & McGregor, A. (2016). A Homolog Pentameric Complex Dictates Viral Epithelial Tropism, Pathogenicity and Congenital Infection Rate in Guinea Pig Cytomegalovirus. PLoS pathogens. 12(7), e1005755-e1005755.
- McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J. (2013). Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease. (pp. 905-925). Academic Press.
- McGregor, A., Yeon Choi, K., & Sung, H. (2012). Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions. Cytomegalovirus Infections: Risk Factors, Causes and Management. (pp. 77-118).