Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus (CMV) which is a common pathogen that establish a life long infection in a mainly latent state. CMV causes disease in transplant patients and is a leading cause of congenital disease in newborns where the virus crosses the placenta and infects the fetus in utero. Congenitally infected newborns can have severe disease that causes cognitive impairment, hearing loss and vision problems. There is no vaccine against congenital CMV and our research seeks to understand the disease and develop interventions strategies.
- University of Glasgow - (Glasgow, United Kingdom), Postdoctoral Training 1997
- Ph.D. in Virology, University of Glasgow - (Glasgow, United Kingdom) 1994
- Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States), Postdoctoral Training
- Choi, K. Y., El-Hamdi, N., & McGregor, A. (2022). Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein.. J Virol. 96(17), e0083122-e00822.
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2022). Cross Strain Protection against Cytomegalovirus Reduces DISC Vaccine Efficacy against CMV in the Guinea Pig Model.. Viruses. 14(4), 760-760.
- Choi, K. Y., & McGregor, A. (2021). A Fully Protective Congenital CMV Vaccine Requires Neutralizing Antibodies to Viral Pentamer and gB Glycoprotein Complexes but a pp65 T-Cell Response Is Not Necessary.. Viruses. 13(8), 1467-1467.
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2021). A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.. J Gen Virol. 102(3),
- Choi, K. Y., El-Hamdi, N., Hornig, J., & McGregor, A. (2021). Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.. J Virol. 95(10), JVI.00324-JVI.00321.
- Mcgregor, A., McVoy, M. A., & Schleiss, M. R. (2013). The Guinea Pig Model of Congenital Cytomegalovirus Infection. Reddehase, M. J. (Eds.), Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol. 2). 88-118. Caister Academic Press.
- McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J. (2013). Chapter 37 Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease. 905-925. Elsevier.
- McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J. (2013). Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease. 905-925. Elsevier.
- McGregor, A., Yeon Choi, K., & Sung, H. (2012). Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions. Cytomegalovirus Infections: Risk Factors, Causes and Management. 77-118.
- McGregor, A., & Schleiss, M. R. (2004). Herpesvirus Genome Mutagenesis by Transposon-Mediated Strategies. Bacterial Artificial Chromosomes. 281-302. Springer Nature.