Our lab studies various herpesviruses but the major focus of our research is on the study of cytomegalovirus (CMV) which is a common pathogen that establish a life long infection in a mainly latent state. CMV causes disease in transplant patients and is a leading cause of congenital disease in newborns where the virus crosses the placenta and infects the fetus in utero. Congenitally infected newborns can have severe disease that causes cognitive impairment, hearing loss and vision problems. There is no vaccine against congenital CMV and our research seeks to understand the disease and develop interventions strategies.
- Cincinnati Children's Hospital Medical Center - (Cincinnati, Ohio, United States), Postdoctoral Training 1999
- University of Glasgow - (Glasgow, United Kingdom), Postdoctoral Training 1997
- Ph.D. in Virology, University of Glasgow - (Glasgow, United Kingdom) 1994
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2021). A trimeric capable gB CMV vaccine provides limited protection against a highly cell associated and epithelial tropic strain of cytomegalovirus in guinea pigs.. Journal of General Virology. 102(3),
- Choi, K. Y., El-Hamdi, N., Hornig, J., & McGregor, A. (2021). Guinea pig cytomegalovirus protective T cell antigen GP83 is a functional pp65 homolog for innate immune evasion and pentamer dependent virus tropism.. J Virol. 95(10),
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2020). Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease. International Journal of Molecular Sciences. 21(17), 5997-5997.
- El-Hamdi, N. S., Choi, K. Y., & McGregor, A. (2020). Guinea pig cytomegalovirus trimer complex gH/gL/gO uses PDGFRA as universal receptor for cell fusion and entry. VIROLOGY. 548, 236-249.
- Choi, K. Y., El-Hamdi, N. S., & McGregor, A. (2020). Requirements for guinea pig cytomegalovirus tropism and antibody neutralization on placental amniotic sac cells.. Journal of General Virology. 101(4), 426-439.
- Mcgregor, A., McVoy, M. A., & Schleiss, M. R. (2013). The Guinea Pig Model of Congenital Cytomegalovirus Infection. Reddehase, M. J. (Eds.), Cytomegaloviruses: From Molecular Pathogenesis to Intervention (Vol. 2). (pp. 88-118). Caister Academic Press.
- McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J. (2013). Chapter 37 Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease. (pp. 905-925).
- McGregor, A., Choi, K. Y., Schachtele, S., & Lokensgard, J. (2013). Human Herpesviruses and Animal Models. Animal Models for the Study of Human Disease. (pp. 905-925). Elsevier.
- McGregor, A., Yeon Choi, K., & Sung, H. (2012). Antiviral and vaccine strategies against cytomegalovirus: Current therapies and future directions. Cytomegalovirus Infections: Risk Factors, Causes and Management. (pp. 77-118).
- McGregor, A., & Schleiss, M. R. (2004). Herpesvirus Genome Mutagenesis by Transposon-Mediated Strategies. Bacterial Artificial Chromosomes. (pp. 281-302).