Mackenzie, Duncan individual record
Associate Professor

Hormones secreted by the thyroid gland are of primary importance in the regulation of such fundamental physiological processes as growth, nutrient utilization, and reproduction. In my laboratory we examine the regulation of the secretion of thyroid hormones and their actions in poikilothermic vertebrates in order to understand the evolution of thyroid function. We are presently focusing on the regulation on thyroid hormone secretion and the mechanisms of iodine transport in commercially-important fish species such as the red drum (Sciaenops ocellatus), the channel catfish (Ictalurus punctatus), and even the zebrafish (Danio rerio).

This research is aimed at providing new insights into the potentially ancient role of thyroid hormones in nutrient assimilation, as well as elucidating evolutionary trends in the regulation of thyroid function. These studies may serve identify ways in which the pituitary-thyroid axis may be manipulated to enhance aquaculture production or endangered species conservation.

selected publications
Academic Articles48
  • Holloway, N., Riley, B., & MacKenzie, D. S. (2021). Expression of the sodium iodide symporter (NIS) in reproductive and neural tissues of teleost fish.. Gen Comp Endocrinol. 300, 113632-113632.
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  • Garner, J. A., MacKenzie, D. S., & Gatlin, D. (2017). Reproductive Biology of Atlantic Leatherback Sea Turtles at Sandy Point, St. Croix: The First 30 Years. Chelonian Conservation and Biology. 16(1), 29-43.
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  • Martinez, B., Soanez-Organis, J. G., Viscarra, J. A., Jaques, J. T., MacKenzie, D. S., Crocker, D. E., & Ortiz, R. M. (2016). Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups.. Am J Physiol Regul Integr Comp Physiol. 310(6), R502-R512.
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  • Martinez, B., Soñanez‐Organis, J., MacKenzie, D., Crocker, D., & Ortiz, R. (2015). Thyroid Gland Remains Responsive to Thyroid Stimulating Hormone With Fasting Duration. The FASEB Journal. 29(S1),
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  • Martinez, B., Soñanez‐Organis, J., MacKenzie, D., Crocker, D., & Ortiz, R. (2014). Glucose infusion increases mRNA expression of deiodinase 1 & 2, and thyroid hormone receptor β‐1 in a fasting‐adapted mammal (1101.12). The FASEB Journal. 28(S1),
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Conference Papers15
  • Holloway, N. D., Mackenzie, D. S., & Riley, B. B. (2020). Evidence for expression of the sodium iodide symporter (NIS) in novel neural and ovarian locations in teleost fish. INTEGRATIVE AND COMPARATIVE BIOLOGY. 60, E104-E104.
  • Wilkes, A. A., Browning, Z., Lenox, M., Jaques, J., & Mackenzie, D. S. (2014). High Resolution Functional Imaging of Fish Endocrine Glands and Target Tissues Using Positron Emission Tomography-Computed Tomography. INTEGRATIVE AND COMPARATIVE BIOLOGY. 54, E369-E369.
  • Jones, R. A., Cohn, W. B., & Mackenzie, D. S. (2014). Regulation of Thyrotropin mRNA Expression in Red Drum, Sciaenops ocellatus. INTEGRATIVE AND COMPARATIVE BIOLOGY. 54, E103-E103.
  • Scobell, S. K., Mackenzie, D. S., Jaques, J. T., & Jones, A. G. (2012). Androgens and female intrasexual aggression in the sex-role reversed Gulf pipefish. INTEGRATIVE AND COMPARATIVE BIOLOGY. 52, E156-E156.
  • Raine, J. C., Cameron, C., Vijayan, M. M., Mackenzie, D. S., & Leatherland, J. F. (2006). A comparison of thyroid hormone receptor gene expression in food-deprived late-stage embryo and juvenile rainbow trout. JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-COMPARATIVE EXPERIMENTAL BIOLOGY. 305A(2), 169-169.
chaired theses and dissertations
First Name
Last Name
mailing address
Texas A&M University; Biology; 3258 TAMU
College Station, TX 77843-3258