It has been long recognized that glycans play a wide spectrum of essential roles in metazoan organisms, while defects in glycosylation are involved in numerous human diseases and abnormalities, from cancer to brain malformation and defects of immune system. However, the complexity of glycosylation pathways and limitations of genetic and in vivo approaches available for studying glycosylation in higher animals significantly impede the research in mammals. We are using the advantages of Drosophila model system, including its decreased genetic redundancy, powerful arsenal of molecular genetic approaches, and comprehensively characterized development, to elucidate mechanisms underlying the function of glycosylation in development and physiology. We employ a multidisciplinary approach to study the roles of several novel glycosyltransferase genes at molecular, cellular, and organismal levels. Currently, our laboratory is involved in two main projects: one project focuses on studying the function of sialylation in the central nervous system, while another project is aimed at elucidation of molecular mechanisms of protein O-mannosylation.

education and training
selected publications
Academic Articles63
  • Chandel, I., Ten Hagen, K. G., & Panin, V. (2019). Sweet rescue or surrender of the failing heart?. J Biol Chem. 294(34), 12579-12580.
    doi badge pubmed badge
  • Chandel, I., Baker, R., Nakamura, N., & Panin, V. (2019). Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo.. J Vis Exp. 2019(149),
    doi badge pubmed badge
  • Baker, R., Nakamura, N., Chandel, I., Howell, B., Lyalin, D., & Panin, V. M. (2018). Protein O-Mannosyltransferases Affect Sensory Axon Wiring and Dynamic Chirality of Body Posture in the Drosophila Embryo.. J Neurosci. 38(7), 1850-1865.
    doi badge pubmed badge
  • Akishina, A. A., Vorontsova, J. E., Cherezov, R. O., Mertsalov, I. B., Zatsepina, O. G., Slezinger, M. S., ... Kuzin, B. A. (2017). Xenobiotic-induced activation of human aryl hydrocarbon receptor target genes in Drosophila is mediated by the epigenetic chromatin modifiers.. Oncotarget. 8(61), 102934-102947.
    doi badge pubmed badge
  • Mertsalov, I. B., Novikov, B. N., Scott, H., Dangott, L., & Panin, V. M. (2016). Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties.. Biochem J. 473(13), 1905-1916.
    doi badge pubmed badge
Conference Papers26
  • Howell, B. A., & Panin, V. M. (2016). Elucidating the role of sialylation in cardiac function using a Drosophila model. GLYCOBIOLOGY. 26(12), 1451-1451.
  • Scott, H., Novikov, B., Mertsalov, I., Caster, C., & Panin, V. (2015). Novel Regulatory Mechanisms Controlling Sialylation in Drosophila Nervous System. GLYCOBIOLOGY. 25(11), 1298-1298.
  • Panin, V., Baker, R., Leon-Aparicio, D., & Guerrero-Hernandez, A. (2015). Pathogenic mechanisms associated with abnormal protein O-mannosylation: Cell culture and Drosophila models. GLYCOBIOLOGY. 25(11), 1308-1308.
  • Meng, Z., Baker, R., Panin, V. M., & Yakovlev, V. V. (2015). Brillouin spectroscopy reveals changes in muscular viscoelasticity in Drosophila POMT mutants. SPIE Proceedings, SPIE BiOS. 9327, 932713-932713-7.
    doi badge
  • Baker, R., Nakamura, N., Lyalin, D., Alfert, M., Guerrero-Hernandez, A., & Panin, V. (2014). Developmental roles and pathogenic mechanisms associated with protein O-mannosylation in Drosophila. GLYCOBIOLOGY. 24(11), 1190-1190.
chaired theses and dissertations
First Name
Last Name
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128