Guo, Shaodong individual record
Associate Professor and Presidential Impact Fellow

The long-term goal of our research is to study the molecular mechanisms of insulin signal transduction, insulin resistance and associated cardiovascular dysfunction, aiming at nutritional and therapeutic intervention for control of metabolic and cardiovascular disorders. My laboratory is focused on the study of cellular signaling and gene transcriptional regulation of metabolic homeostasis that are governed by the PI3K->Akt->FoxO pathway, with the hope of understanding how dysregulation of this pathway in insulin/IGF-1 action causes liver damage, cardiovascular dysfunction, and pancreatic beta cell failure, resulting in diabetes, obesity, and organ failure.

education and training
selected publications
Academic Articles57
  • Yang, W., Yan, H., Pan, Q., Shen, J. Z., Zhou, F., Wu, C., Sun, Y., & Guo, S. (2019). Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1.. J Endocrinol. 241(3), 265-278.
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  • Villarreal, D., Pradhan, G., Wu, C., Allred, C. D., Guo, S., & Sun, Y. (2019). A Simple High Efficiency Protocol for Pancreatic Islet Isolation from Mice.. J Vis Exp. (150),
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  • Yan, H., Yang, W., Zhou, F., Li, X., Pan, Q., Shen, Z., ... Guo, S. (2019). Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.. Diabetes. 68(2), 291-304.
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  • Zhang, K., Guo, X., Yan, H., Wu, Y., Pan, Q., Shen, J. Z., ... Guo, S. (2019). Phosphorylation of Forkhead Protein FoxO1 at S253 Regulates Glucose Homeostasis in Mice.. Endocrinology. 160(5), 1333-1347.
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  • Xu, H., Li, X., Adams, H., Kubena, K., & Guo, S. (2018). Etiology of Metabolic Syndrome and Dietary Intervention.. Int J Mol Sci. 20(1), 128-128.
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in the news
First Name
Last Name
mailing address
Texas A&M University; Department of Nutrition; 123A-Cater-Mattil Hall; 2253 TAMU
College Station, TX 77843-2253