Muthuchamy, Mariappan individual record

The main goal of our laboratory is to understand the molecular mechanisms of cardiac muscle dynamics in normal and diseased states. Particularly, our interests focus on the relationships between thin filament activation and crossbridge kinetics, and how the mechanotransduction signaling transmits to myofilament activation. We use multiple techniques, molecular, cellular, biochemistry, structural and biophysical, to obtain information on the fundamental regulatory mechanisms of cardiac muscle contraction.

education and training
selected publications
Academic Articles68
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  • Lopez Gelston, C. A., Balasubbramanian, D., Abouelkheir, G. R., Lopez, A. H., Hudson, K. R., Johnson, E. R., ... Rutkowski, J. M. (2018). Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice.. Circ Res. 122(8), 1094-1101.
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  • Lee, Y., Chakraborty, S., Meininger, C. J., & Muthuchamy, M. (2018). Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium.. Microcirculation. 25(7), e12492-e12492.
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  • Kim, J., Chakraborty, S., Jayaprakasha, G. K., Muthuchamy, M., & Patil, B. S. (2017). Citrus nomilin down-regulates TNF--induced proliferation of aortic smooth muscle cells via apoptosis and inhibition of IB.. Eur J Pharmacol. 811, 93-100.
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  • Foskett, A. M., Chakraborty, S., & Muthuchamy, M. (2013). Lymphangiogenesis. Immunology of the Lymphatic System. 3-33. Springer New York.
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chaired theses and dissertations
First Name
Last Name
mailing address
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS
College Station, TX 77843-1114