overview
Research Interests: Understanding pathophysiology and developing treatment strategies for neurodegenerative conditions including Gulf War Illness, Traumatic Brain Injury, Aging, Alzheimer's Disease and Temporal Lobe Epilepsy,
Expertise: Developing experimental models for Gulf War Illness, Traumatic Brain Injury, and Temporal Lobe Epilepsy, Survival surgeries for transplantation of cells and chronic EEG recordings, isolation of microglia and astrocytes from rodent brains, functional assessment in rodents by neurocognitive tests, investigation of modulation of neuroinflammation and neurogenesis at the cellular and molecular level, human mesenchymal stem cell cultures and isolation of extracellular Vesicles.
education and training
- Ph.D. in Cancer Cell Biology, Kasturba Medical College - (Manipala, Karnataka, India) 2010
- M.Sc. in (Medical) Biochemistry, Kasturba Medical College - (Manipala, Karnataka, India) 2000
- B.Sc. in Biochemistry, Microbiology, First class, Acharya Nagarjuna University - (Guntur, Andhra Pradesh, India) 1997
selected publications
Academic Articles40
- Kodali, M., Jankay, T., Shetty, A. K., & Reddy, D. S. (2023). Pathophysiological basis and promise of experimental therapies for Gulf War Illness, a chronic neuropsychiatric syndrome in veterans.. Psychopharmacology. 240(4), 673-697.
- Kodali, M., Madhu, L. N., Reger, R. L., Milutinovic, B., Upadhya, R., Gonzalez, J. J., ... Shetty, A. K. (2023). Intranasally administered human MSC-derived extracellular vesicles inhibit NLRP3-p38/MAPK signaling after TBI and prevent chronic brain dysfunction.. 108, 118-134.
- Attaluri, S., Arora, M., Madhu, L. N., Kodali, M., Shuai, B., Melissari, L., ... Shetty, A. K. (2022). Oral Nano-Curcumin in a Model of Chronic Gulf War Illness Alleviates Brain Dysfunction with Modulation of Oxidative Stress, Mitochondrial Function, Neuroinflammation, Neurogenesis, and Gene Expression.. Aging and Disease. 13(2), 583-613.
- Madhu, L. N., Kodali, M., & Shetty, A. K. (2022). Promise of metformin for preventing age-related cognitive dysfunction.. Neural Regeneration Research. 17(3), 503-507.
- Attaluri, S., Upadhya, R., Kodali, M., Madhu, L. N., Upadhya, D., Shuai, B., & Shetty, A. K. (2022). Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness.. Frontiers in Immunology. 13, 853000.
Conference Papers8
- Madhu, L. N., Attaluri, S., Kodali, M., Melissari, L., Shuai, B., Upadhya, R., & Shetty, A. K. (2019). Brain Dysfunction in a Model of Gulf War Illness Continues into Middle Age with Elevated Oxidative Stress and Waned Mitochondrial Activity. Cell Transplantation. 28(4), 476-477.
- Kain, J., Petrescu, A., Grant, S., Frampton, G. A., McMillin, M., Wyatt, A., ... DeMorrow, S. (2017). Exposure to gulf war illness-related chemicals increases susceptibility to cholestatic liver injury by enhancing CD11b+macrophage/monocyte infiltration into the liver. Hepatology. 66, 942A-942A.
- Kodali, M., Shuai, B., Mishra, V., Attaluri, S., Hattiangady, B., & Shetty, A. K. (2016). Moderate Running Exercise Improves Cognitive, Memory, and Mood Function With Increased Neurogenesis in a Gulf War Illness Model. Cell Transplantation. 25(4), 764-765.
- Kodali, M., Upadhya, R., Attaluri, S., Madhu, N. L., Shuai, B., & Shetty, K. A. REPEATED CLOSED HEAD INJURY LEADS TO LONGTERM COGNITIVE AND MOOD IMPAIRMENTS WITH ELEVATED OXIDATIVE STRESS, NEUROINFLAMMATION AND REDUCED HIPPOCAMPAL NEUROGENESIS. Journal of Neurotrauma. 40(15-16), A79-A80.
- DeMorrow, S., Kain, J., Grant, S., Frampton, G., McMillin, M., Wyatt, A., ... Petrescu, A. Prolonged Low-Level Inflammation Due to Exposure to Gulf War Illness Related Chemicals Increases Susceptibility to Cholestatic Liver Injury by Enhancing CD11b+ Macrophage/Monocyte Infiltration into the Liver. American Journal of Pathology. 187(10), 2368-2368.
Repository Documents / Preprints2
- Bryant, J. D., Kodali, M., Shuai, B., Menissy, S. S., Graves, P. J., Shetty, A. K., West, L. C., & West, A. P. (2020). Innate immune signaling and sex differences contribute to neurocognitive impairment, neuroinflammation, and mitochondrial rewiring in a mouse model of Gulf War illness.
- Madhu, L. N., Kodali, M., Upadhya, R., Rao, S., Shuai, B., Somayaji, Y., ... Shetty, A. K. Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model..
Email
kodali@tamu.edu
First Name
Maheedhar
Last Name
Kodali
UN Sustainable Development Goals:
UN Sustainable Development Goals: