Srinivasan, Rahul individual record
Assistant Professor
overview

My research focuses on developing a mechanistic understanding of neurodegeneration, with the goal of discovering novel strategies to treat neurodegenerative disorders. In this regard, I am interested in two primary areas: (1) Understanding the role of astrocytes in neurodegeneration and (2) Elucidating molecular mechanisms underlying the known neuroprotective effects of nicotine in Parkinson's disease.

We utilize a broad range of techniques spanning the spectrum from molecules to mice. Our methods include stereotaxic injections of adeno-associated viruses (AAVs) into the mouse brain, advanced imaging techniques such as Ca2+ imaging in live brain slices using genetically encoded calcium sensors (GCaMPs), in vitro and slice electrophysiology, advanced molecular biology, including creation of transgenic mice and tissue culture.

selected publications
Academic Articles43
  • Bancroft, E. A., De La Mora, M., Pandey, G., Zarate, S. M., & Srinivasan, R. (2022). Extracellular S100B inhibits A-type voltage-gated potassium currents and increases L-type voltage-gated calcium channel activity in dopaminergic neurons.. Glia. 70(12), 2330-2347.
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  • Bancroft, E. A., De La Mora, M., Pandey, G., Zarate, S. M., & Srinivasan, R. (2022). Cover Image, Volume 70, Issue 12. Glia. 70(12), c1-c1.
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  • Branyan, T. E., Selvamani, A., Park, M. J., Korula, K. E., Kosel, K. F., Srinivasan, R., & Sohrabji, F. (2022). Functional Assessment of Stroke-Induced Regulation of miR-20a-3p and Its Role as a Neuroprotectant.. Transl Stroke Res. (3), 432-448.
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Chapters1
  • Venugopal, S., Srinivasan, R., & Khakh, B. S. (2019). GECIquant: Semi-automated Detection and Quantification of Astrocyte Intracellular Ca2+ Signals Monitored with GCaMP6f. De Pittà, M., & Berry, H. (Eds.), Computational Glioscience. 455-470. Springer International Publishing.
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Conference Papers1
  • Branyan, T. E., Srinivasan, R., & Sohrabji, F. (2019). MicroRNA (miR)20a-3p preserves astrocyte mitochondrial function under ischemic conditions. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 39, 460-460.
patents
Patents1
Email
rahul@tamu.edu
First Name
Rahul
Last Name
Srinivasan
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807
USA