overview

My research program focuses on brain-immune interactions regulated by estrogen and its implications for neuro-inflammatory diseases such as stroke in women. Additionally, I am also interested in estrogens interactions with other endogenous and environmental endocrine mediators, including Vitamin D hormone and the peptide hormone Insulin-like Growth Factor (IGF)-1. Our current studies use an animal model to examine age and sex differences in recovery from stroke, focusing at the cellular level on the endothelium and astrocytes, which are the principal components of the blood brain barrier. At the molecular level, we are examining sex and age differences in miRNA and epigenetic markers, with a view to developing biomarkers for diseases and uncovering new therapeutic targets.

selected publications
Academic Articles56
Chapters1
  • Guerlain, S., Smith, P. J., Smith, J. W., Rudmann, S., Obradovich, J. H., & Strohm, P. (2018). Decision support in medical systems. Automation and Human Performance: Theory and Applications. (pp. 385-406). Routledge.
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Conference Papers28
  • Iyengar, M. S., Svirbeiy, J. R., Rusu, M., & Smith, J. W. (2008). VITA - An interactive 3-D visualization system to enhance student understanding of mathematical concepts in medical decision-making. PROCEEDINGS OF THE 21ST IEEE INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS. 434- .
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  • Mirhaji, P., Zhang, J., Srinivasan, A., Richesson, R. L., & Smith, J. W. (2004). Knowledge based public health situation awareness. MATHEMATICAL MODELING AND ESTIMATION TECHNIQUES IN COMPUTER VISION. 5403(PART 1), 198-209.
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  • Mirhaji, P., Richesson, R. L., Turley, J. P., Zhang, J., & Smith, J. W. (2004). Public health situation awareness, towards a semantic approach. MATHEMATICAL MODELING AND ESTIMATION TECHNIQUES IN COMPUTER VISION. 5434, 339-350.
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  • Mirhaji, P., Zhang, J., Smith, J. W., Madjid, M., Casscells, S. W., & Lillibridge, S. R. (2003). Informatics Critical to Public Health Surveillance. MATHEMATICAL MODELING AND ESTIMATION TECHNIQUES IN COMPUTER VISION. 5071, 151-163.
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  • Kantor, G., Svirbely, J. R., Johnson, K., Sriram, M., Rodriguez, J. R., & Smith, J. (2001). MEDAL: The medical algorithm project. MEDINFO 2017: PRECISION HEALTHCARE THROUGH INFORMATICS. 84, 298.
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Email
jwsmith7@tamu.edu
First Name
Jack
Last Name
Smith
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77840
USA