My laboratory uses an integrative approach to elucidate the molecular basis of cyto/nucleo morphogenesis in the spermatid, called spermiogenesis. This is among the most drastic cellular reorganizations and is critical for both male fertility and high fidelity transmission of genetic and epigenetic information to the next generation for healthy offspring. We seek to elucidate structural and regulatory processes involved in this transformation to understand the molecular underpinnings of cytoskeletal and chromatin remodeling in normal and disrupted spermiogenesis. The laboratory takes advantage of molecular and genetic tools in mouse models including transgenesis, gene knock out studies, and genomic and proteomic expression analyses, advanced imaging technologies for morphological and live tissue imaging, and protein expression and in vitro molecular biochemical approaches such as actin dynamics assays.

education and training
selected publications
Academic Articles16
Conference Papers1
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mailing address
Texas A&M University; Vet Med - Physiology & Pharmacology; 4466 TAMU
College Station, TX 77843-4466