Igumenova, Tatyana individual record
Associate Professor
overview

My laboratory is broadly interested in understanding the structural basis of signal transduction events that occur at the membrane surface. These events are mediated by signaling proteins that reversibly associate with membranes in response to binding second messengers, such as Ca2+ ions, diacylglycerol, and phosphoinositides. One of the key kinases regulating these signal transduction pathways is the Protein Kinase C (PKC) family. Aberrant levels of PKC expression or activity have been implicated in a large number of human diseases, such as cancer, cardiac failure, Alzheimer's disease, and diabetes. Despite the significance of PKC in signal transduction and human health, the structural and dynamical basis of its activation upon binding to lipid membranes remains elusive.

education and training
selected publications
Academic Articles38
  • You, Y., Katti, S., Yu, B., Igumenova, T. I., & Das, J. (2021). Probing the Diacylglycerol Binding Site of Presynaptic Munc13‑1. 60(16), 1286-1298.
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  • Katti, S., & Igumenova, T. I. (2021). Structural insights into C1-ligand interactions: Filling the gaps by in silico methods. 79, 100784-100784.
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  • Taylor, J. T., Mukherjee, P. K., Puckhaber, L. S., Dixit, K., Igumenova, T. I., Suh, C., Horwitz, B. A., & Kenerley, C. M. (2020). Deletion of the Trichoderma virens NRPS, Tex7, induces accumulation of the anti-cancer compound heptelidic acid. 529(3), 672-677.
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  • Katti, S., Nyenhuis, S. B., Her, B., Cafiso, D. S., & Igumenova, T. I. (2020). Partial Metal Ion Saturation of C2 Domains Primes Synaptotagmin 1-Membrane Interactions. 118(6), 1409-1423.
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chaired theses and dissertations
Email
tigumenova@tamu.edu
First Name
Tatyana
Last Name
Igumenova
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128
USA