Scholars

Bondos, Sarah

Associate Professor

Positions:

Associate Professor, Molecular and Cellular Medicine, College of Medicine

Single Page Bio

bondos@tamu.edu

1 979 845 5399

Co-author Network

Map of Science

Co-investigator Network

overview

My laboratory works in two research areas. First, we are combining biophysical and genetic approaches to understand how proteins use unstructured regions to sense cellular information and respond by adjusting their function. We developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, and have used this unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Second, we discovered methods to self-assemble Ultrabithorax into robust, extensible materials that are biocompatible and provide unique opportunities for functionalization. These materials are being developed for use as biosensors and to pattern and instruct vascularization in tissue engineering scaffolds.

education and training

Rice University - (Houston, Texas, United States), Postdoctoral Training 2003
Ph.D. in Biochemistry, University of Illinois at Urbana Champaign - (Urbana, Illinois, United States) 1998
B.S. in Chemistry, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 1993

selected publications

Academic Articles41

Booth, R., Churion, K., Bystroff, C., & Bondos, S. (2020). Binding, Release, and Detection of Ligands by Ultrabithorax Protein‐Based Materials. FASEB J. 34(S1), 1-1.
Bondos, S., Churion, K., Booth, R., & Tippelt, S. (2020). Shape-Shifting to Regulate and Diversify Transcription Factor Function. BIOPHYSICAL JOURNAL. 118(3), 480a-481a.
Mendes, G. G., Booth, R. M., Pattison, D. L., Alvarez, A. J., & Bondos, S. E. (2018). Generating Novel Materials Using the Intrinsically Disordered Protein Ubx. MACROMOLECULAR CRYSTALLOGRAPHY, PT D. 611(International Journal of Molecular Sciences 1), 583-605.
Bondos, S., Howell, D., Tsai, S., & Bayless, K. (2018). Functionalizing Protein‐based Materials with Biomolecules. FASEB J. 32(S1), 230.1-230.1.
Liu, Y., Huang, A., Booth, R. M., Mendes, G. G., Merchant, Z., Matthews, K. S., & Bondos, S. E. (2018). Evolution of the activation domain in a Hox transcription factor. The International Journal of Developmental Biology. 62(11-12), 745-753.

Chapters4

Bondos, S. E., Mendes, G. G., & Jons, A. (2020). Context-dependent HOX transcription factor function in health and disease. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 77. Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B. (pp. 225-262). Elsevier.
Churion, K., Liu, Y., Hsiao, H., Matthews, K. S., & Bondos, S. E. (2014). Measuring Hox-DNA Binding by Electrophoretic Mobility Shift Analysis. Methods in Molecular Biology. Hox Genes. (pp. 211-230). Springer New York.
Bondos, S. E., & Churion, K. A. (2012). Identifying solubility-promoting buffers for intrinsically proteins prior to purification. Uversky, V. N., & Dunker, A. K. (Eds.), Intrinsically Disordered Protein Analysis Volume 2, Methods and Experimental Tools. (pp. 415-427). Humana Press.
Bondos, S. E., & Hsiao, H. (2012). Roles for Intrinsic Disorder and Fuzziness in Generating Context-specific Function in Ultrabithorax, a Hox Transcription Factor. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. Fuxreiter, M., & Tompa, P. (Eds.), Fuzziness. (pp. 86-105). Springer US.

Conference Papers10

Bondos, S. E. (2019). The critical role of intrinsic disorder in creating bioactive materials. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. 37, 10-11.
Banerjee, S., Jordan, T. B., Fraser, K., Reimertz, J., Crone, E. E., Bunn, A. L., ... Bystroff, C. (2019). Computationally Guided Rational Design of LOO-GFP Biosensors and Biosensor Materials. BIOPHYSICAL JOURNAL. 116(3), 443a-443A.
Liu, Y., Huang, A., Booth, R., Mendes, G., Merchant, Z., Matthews, K. S., & Bondos, S. E. (2019). Evolution of the Intrinsically Disordered Activation Domain in a Hox Transcription Factor. BIOPHYSICAL JOURNAL. 116(3), 178a-179a.
Booth, R. M., Churion, K., Alvarez, A. J., Ramasamy, S., & Bondos, S. E. (2019). Dna delivery to cells by ultabithorax protein-based materials. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 571.
Mendes, G. G., Howell, D. W., Tsai, S. P., Bayless, K. J., & Bondos, S. E. (2019). Engineering ubx-based materials to promote and guide neovascularization. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 26.