Scholars

Bondos, Sarah

Assistant Professor

Positions:

Assistant Professor, Molecular and Cellular Medicine, College of Medicine

Single Page Bio

bondos@tamu.edu

1 979 845 5399

Co-author Network

Map of Science

overview

My laboratory works in two research areas. First, we are combining biophysical and genetic approaches to understand how proteins use unstructured regions to sense cellular information and respond by adjusting their function. We developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, and have used this unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Second, we discovered methods to self-assemble Ultrabithorax into robust, extensible materials that are biocompatible and provide unique opportunities for functionalization. These materials are being developed for use as biosensors and to pattern and instruct vascularization in tissue engineering scaffolds.

education and training

Rice University - (Houston, Texas, United States), Postdoctoral Training 2003
Ph.D. in Biochemistry, University of Illinois at Urbana Champaign - (Urbana, Illinois, United States) 1998
B.S. in Chemistry, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 1993

selected publications

Academic Articles37

Liu, Y., Huang, A., Booth, R. M., Mendes, G. G., Merchant, Z., Matthews, K. S., & Bondos, S. E. (2018). Evolution of the activation domain in a hox transcription factor. Int J Dev Biol. 62(11-12), 745-753.
Mendes, G. G., Booth, R. M., Pattison, D. L., Alvarez, A. J., & Bondos, S. E. (2018). Generating Novel Materials Using the Intrinsically Disordered Protein Ubx. ENZYME KINETICS AND MECHANISM, PT D.
Hsiao, H., Santos, A., Howell, D. W., Patterson, J. L., Fuchs-Young, R., & Bondos, S. E. (2016). Culture of Tumorigenic Cells on Protein Fibers Reveals Metastatic Cell Behaviors. BIOMACROMOLECULES. 17(11), 3790-3799.
Howell, D. W., Duran, C. L., Tsai, S., Bondos, S. E., & Bayless, K. J. (2016). Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Angiogenic Activity. BIOMACROMOLECULES. 17(11), 3558-3569.
Churion, K. A., Rogers, R. E., Bayless, K. J., & Bondos, S. E. (2016). Separating full-length protein from aggregating proteolytic products using filter flow-through purification. ANALYTICAL BIOCHEMISTRY. 514, 8-11.

Chapters3

Churion, K., Liu, Y., Hsiao, H., Matthews, K. S., & Bondos, S. E. (2014). Measuring Hox-DNA binding by electrophoretic mobility shift analysis.. Methods in molecular biology (Clifton, N.J.). Methods in Molecular Biology. (pp. 211-230). Springer New York.
Bondos, S. E., & Churion, K. A. (2012). Identifying solubility-promoting buffers for intrinsically proteins prior to purification. Uversky, V. N., & Dunker, A. K. (Eds.), Intrinsically Disordered Protein Analysis Volume 2, Methods and Experimental Tools. (pp. 415-427). Humana Press.
Bondos, S. E., & Hsiao, H. (2012). ROLES FOR INTRINSIC DISORDER AND FUZZINESS IN GENERATING CONTEXT-SPECIFIC FUNCTION IN ULTRABITHORAX, A HOX TRANSCRIPTION FACTOR. MECHANISMS IN THE PATHOGENESIS OF ENTERIC DISEASES 2. Fuxreiter, M., & Tompa, P. (Eds.), FUZZINESS: STRUCTURAL DISORDER IN PROTEIN COMPLEXES. (pp. 86-105). Springer Us.

Conference Papers9

Banerjee, S., Jordan, T. B., Fraser, K., Reimertz, J., Crone, E. E., Bunn, A. L., ... Bystroff, C. (2019). Computationally Guided Rational Design of LOO-GFP Biosensors and Biosensor Materials. Biophys J. 116(3), 443A-443A.
Booth, R. M., Churion, K., Alvarez, A. J., Ramasamy, S., & Bondos, S. E. (2019). Dna delivery to cells by ultabithorax protein-based materials. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 571.
Mendes, G. G., Howell, D. W., Tsai, S. P., Bayless, K. J., & Bondos, S. E. (2019). Engineering ubx-based materials to promote and guide neovascularization. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 26.
Liu, Y., Huang, A., Booth, R., Mendes, G., Merchant, Z., Matthews, K. S., & Bondos, S. E. (2019). Evolution of the Intrinsically Disordered Activation Domain in a Hox Transcription Factor. Biophys J. 116(3), 178A-179A.
Howell, D., Tsai, S., Churion, K., Patterson, J., Bayless, K., & Bondos, S. E. (2016). Mechanically-Tunable, Protein-Based Materials Can be Functionalized with Other Proteins and with DNA. Biophys J. 110(3), 338A-338A.