Cruz-Reyes, Jorge individual record
Professor
overview

We combine approaches in molecular genetics, structural biology, biochemistry, proteomics, and bioinformatics to study the amazing RNA biology of trypanosome parasites. One research line is on an RNA editing process by uridine insertion and deletion that creates amino acid coding triplets in most mRNAs. Yet a single error in the U-changes yields a frame-shift. Trypanosomes split from other eukaryotic lineages over a hundred million years ago, yet this editing has analogies with RNAi, CRISPR/Cas9, mRNA splicing and other systems directed by small non-coding RNAs (ncRNAs).

selected publications
Academic Articles38
  • Aphasizheva, I., Alfonzo, J., Carnes, J., Cestari, I., Cruz-Reyes, J., Göringer, H. U., ... Aphasizhev, R. (2020). Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.. Trends Parasitol. 36(4), 337-355.
  • Chenna, B. C., Li, L., Mellott, D. M., Zhai, X., Siqueira-Neto, J. L., Calvet Alvarez, C., ... Meek, T. D. (2020). Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.. J Med Chem. 63(6), 3298-3316.
  • Kumar, V., Doharey, P. K., Gulati, S., Meehan, J., Martinez, M. G., Hughes, K., Mooers, B., & Cruz-Reyes, J. (2019). Protein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomes.. PLoS One. 14(4), e0211525-e0211525.
    doi badge pubmed badge
  • Kumar, V., Doharey, P. K., Gulati, S., Meehan, J., Martinez, M. G., Hughes, K., Mooers, B., & Cruz-Reyes, J. (2019). Protein features for assembly of the RNA editing helicase 2 subcomplex (REH2C) in Trypanosome holo-editosomes. 524702.
    doi badge
  • Cruz-Reyes, J., Mooers, B., Doharey, P. K., Meehan, J., & Gulati, S. (2018). Dynamic RNA holo-editosomes with subcomplex variants: Insights into the control of trypanosome editing.. Wiley Interdiscip Rev RNA. 9(6), e1502.
Books1
  • doi badge pubmed badge
Chapters2
  • Cruz-Reyes, J., & Hernandez, A. (2008). Protein–Protein and RNA–Protein Interactions in U-Insertion/Deletion RNA Editing Complexes. RNA and DNA Editing. 71-98. John Wiley & Sons, Inc..
    doi badge
  • Spice, W. M., Cruz-Reyes, J. A., & Ackers, J. P. (1992). Entamoeba histolytica. Molecular and Cell Biology of Opportunistic Infections in AIDS. 95-137. Springer Netherlands.
editor of
Books1
chaired theses and dissertations
Email
cruzrey@tamu.edu
First Name
Jorge
Last Name
Cruz-Reyes
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128
USA