Dr. Aramayo's laboratory is centered on understanding the function(s) of RNAs, especially non-coding RNAs in all aspects of Biology. While the initial work was based on studying Meiotic Silencing in Neurospora, it became immediately clear that the RNA silencing mechanism invoked by this very unusual genetic phenomenon had been adapted and evolved to fulfill key highly-related roles in all eukaryotic cells. The complexity of the problem demanded the use of the most sophisticated molecular tools, especially Next Generation DNA Sequencing and the manipulation of the emerging information. In the process of mastering these computational tools and techniques, the Aramayo lab branched into studying the Computational Genomics aspect of these problems. The expertise thus generated could clearly be applied to all organisms and/or other systems. The Aramayo laboratory thus established active collaborations with researchers studying the biology of RNAs in Neurobiology, Muscular Distrophy and Cell Cycle. The computational expertise of this laboratory has also generated an active collaboration with Materials Sciences. The wet-lab aspect of this laboratory is still centered on understanding Meiotic Silencing, one of the most amazing and intriguing mechanisms observed in meiotic cells of eukaryotic organisms. The long term objective of our work is to understand meiotic silencing in Neurospora and to map its connections with the meiotic silencing observed in other organisms.
- Stanford University - (Stanford, California, United States), Postdoctoral Training 1997
- University of Wisconsin - Madison - (Madison, Wisconsin, United States), Postdoctoral Training 1993
- Ph.D. in Genetics, University of Georgia - (Athens, Georgia, United States) 1992
- M.S. in Molecular Biology, University of Brasilia - (Brasília, Brazil) 1986
- B.S. in Molecular Biology, University of Brasilia - (Brasília, Brazil) 1982
- Mateos, M., Silva, N. O., Ramirez, P., Higareda-Alvear, V. M., Aramayo, R., & Erickson, J. W. (2019). Effect of heritable symbionts on maternally-derived embryo transcripts. SCIENTIFIC REPORTS. 9(1), 8847.
- Aramayo, R., & Polymenis, M. (2017). Ribosome profiling the cell cycle: lessons and challenges.. Curr Genet. 63(6), 959-964.
- Clanton, R. M., Wu, G., Akabani, G., & Aramayo, R. (2017). Control of seizures by ketogenic diet-induced modulation of metabolic pathways. AMINO ACIDS. 49(1), 1-20.
- Stavrianakou, M., Perez, R., Wu, C., Sachs, M. S., Aramayo, R., & Harlow, M. (2017). Draft de novo transcriptome assembly and proteome characterization of the electric lobe of Tetronarce californica: a molecular tool for the study of cholinergic neurotransmission in the electric organ. BMC GENOMICS. 18(1), 611.
- Li, H., Wu, C., Aramayo, R., Sachs, M. S., & Harlow, M. L. (2017). Synaptic vesicles isolated from the electric organ of Torpedo californica and from the central nervous system of Mus musculus contain small ribonucleic acids (sRNAs). Genomics Data. 12, 52-53.
- Clanton, Ryan Michael (2017-12). Targeting Locoregional Characteristics of Neoplasms. (Doctoral Dissertation)
- Suesc?n Torres, Ana Victoria (2014-08). Sexual Development and Meiotic Silencing in Neurospora crassa. (Doctoral Dissertation)
- Pratt, Robert James (2008-12). Meiotic trans-sensing and meiotic silencing in neurospora crassa. (Doctoral Dissertation)
- Anzola Lagos, Juan Manuel (2008-12). Computational identification and evolutionaty enalysis of metazoan micrornas. (Doctoral Dissertation)
- McLaughlin, Malcolm Thomas (2007-12). A dicer-like protein is essential for normal sexual development and meiotic silencing in the filamnentous fungus neurospora crassa. (Master's Thesis)