Qin, Hongmin individual record
Associate Professor
Positions:
overview

Live bioreactor for synthetic biology

The lab is developing live bioreactors to synthesize products of commercial value. The system we are developing is capable of resisting contamination, and withstanding harsh conditions. We are translating the technology developed for potential industrial usages.



The biogenesis of a cilium/flagellum

Our lab is interested in the conceptual frameworks that govern organelle biogenesis and the corresponding regulations. The current main research effort in our lab is to understand. Cilia and flagella are microtubule-based appendages extending from the basal body of almost all eukaryotic cells, and are classified as either motile or primary. Motile cilia or flagella such as Chlamydomonas flagella, sperm flagella and respiratory tract epithelial cell cilia are responsible for movement or generation of fluid flow. In contrast, primary cilia are non-motile organelles that are critically involved in visual, olfactory and auditory signal transduction and play key roles in regulation of gene expression, development and animal behavior. Ciliary defects are linked to ciliopathies such as polycystic kidney disease, nephronophthisis, retinal degeneration, situs inversus, hydrocephalus, polydactyly and obesity. Our lab uses a combination of biochemistry, cell biology, and genetics approaches to understand the principles of ciliogenesis and its regulation.



Flagellar axoneme structure and motility

The waveform of cilia is conserved, no matter whether the cilia are on green algae Chlamydomonas or mammalian epithelia found in the airways, the uterus and fallopian tubes, the efferent ducts of the testes, and the ventricular system of the brain. These motile cilia beat with a conserved planar asymmetrical waveform. We are beginning to learn how the asymmetry of the waveform is established and the mutant analyses are underway.

education and training
selected publications
Academic Articles36
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  • Ishikawa, H., Tian, J. L., Yu, J. E., Marshall, W. F., & Qin, H. (2022). Biosynthesis of Linear Protein Nanoarrays Using the Flagellar Axoneme. ACS Synthetic Biology. 11(4), 1454-1465.
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  • Ma, R., Hendel, N. L., Marshall, W. F., & Qin, H. (2020). Speed and Diffusion of Kinesin-2 Are Competing Limiting Factors in Flagellar Length-Control Model. Biophysical Journal. 118(11), 2790-2800.
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  • Finetti, F., Pan, J., Qin, H., & Delaval, B. (2020). Editorial: Dissecting the Intraflagellar Transport System in Physiology and Disease: Cilia-Related and -Unrelated Roles. Frontiers in Cell and Developmental Biology. 8, 615588.
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Chapters1
  • Alejandro, D., Richey, E., & Qi, H. (2012). Biology of Cilia and Ciliopathies. Current Frontiers and Perspectives in Cell Biology. InTech.
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Conference Papers5
  • Ishikawa, H., Yu, J., Tian, J., Tang, S., Qin, H., & Marshall, W. F. (2019). Cell-based biosynthesis of linear protein nanoarrays. Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XI. 10893, 108930f-108930f-16.
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  • Ishikawa, H., Ide, T., Yagi, T., Jiang, X., Yanagisawa, H., Sasaki, H., ... Marshall, W. (2012). TTC26/DYF13 undergoes intraflagellar transport and is required for cilia/flagella formation and transport of inner dynein components into flagella.. MOLECULAR BIOLOGY OF THE CELL. 23,
  • Wang, Z., Qin, H., Diener, D., & Rosenbaum, J. (2006). Knockdown of IFT27 Lead to Severe Cell Cycle Defect in Chlamydomonas. MOLECULAR BIOLOGY OF THE CELL. 17,
  • Bae, Y., Knobel, K., Qin, H., Hu, J., Rosenbaum, J., & Barr, M. (2006). Mechanisms of Polycystin Ciliary Localization in C-elegans. MOLECULAR BIOLOGY OF THE CELL. 17,
Repository Documents / Preprints2
  • Ishikawa, H., Tian, J. L., Yu, J. E., Marshall, W. F., & Qin, H. (2021). Biosynthesis of linear protein nanoarrays using the flagellar axoneme.
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  • Liu, Y. i., Visetsouk, M., Mynlieff, M., Qin, H., Lechtreck, K. F., & Yang, P. (2017). H+- and Na+-elicited swift changes of the microtubule system in the biflagellated green alga Chlamydomonas.
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researcher on
chaired theses and dissertations
Email
hqin@tamu.edu
First Name
Hongmin
Last Name
Qin
mailing address
Texas A&M University; Biology; 3258 TAMU
College Station, TX 77843-3258
USA