- Professor, Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences
- Associate Dean for Research and Graduate Studies, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University
My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.
- Ph.D. in Microbiology and Immunology, University of Miami - (Coral Gables, Florida, United States) 2003
- M.S. in Molecular Biology, East Carolina University - (Greenville, North Carolina, United States) 1997
- B.S. in Biology, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 1993
- Criscitiello, M. F. (2021). Unusual T cell receptor in opossum. SCIENCE. 371(6536), 1308-1309.
- Kinlein, A., Janes, M. E., Kincer, J., Almeida, T., Matz, H., Sui, J., ... Ohta, Y. (2021). Analysis of shark NCR3 family genes reveals primordial features of vertebrate NKp30. Immunogenetics. 73(4), 333-348.
- Ott, J. A., Ohta, Y., Flajnik, M. F., & Criscitiello, M. F. (2021). Lost structural and functional inter-relationships between Ig and TCR loci in mammals revealed in sharks. Immunogenetics. 73(1), 17-33.
- Oliveira, T., Burlamaqui, T., Sá, A., Breaux, B., Luna, F., Attademo, F., ... Schneider, M. (2021). TLR4 and TLR8 variability in Amazonian and West Indian manatee species from Brazil.. Genetics and Molecular Biology. 44(2), e20190252.
- Mitchell, C. D., & Criscitiello, M. F. (2020). Comparative study of cartilaginous fish divulges insights into the early evolution of primary, secondary and mucosal lymphoid tissue architecture. Fish & Shellfish Immunology. 107(Pt B), 435-443.
- Vadnais, M. L., Criscitiello, M. F., & Smider, V. V. (2017). Antibodies from Other Species. Protein Therapeutics. (pp. 85-112). Wiley-VCH Verlag GmbH & Co. KGaA.
- Criscitiello, M. F. (2014). Shark Immunoglobulin Light Chains. Immunobiology of the SHARK. (pp. 221-235). CRC Press.
- Criscitiello, M. F. (2014). Shark T-Cell Receptors. Immunobiology of the SHARK. (pp. 237-248). CRC Press.
- Criscitiello, M. F. (2020). Activation Induced Cytidine Deaminase and the Evolution of Antigen Receptor Immunogenetics. Journal of Immunology. 204(1),
- Mitchell, C. D., & Criscitiello, M. F. (2020). Code Blue: Nurse Cells Can Resuscitate Lymphocyte Receptors in Nurse Shark Thymus by Secondary Rearrangement. Journal of Immunology. 204(1),
- Ott, J. A., Harrison, J., Ota, Y., Flajnik, M. F., & Criscitiello, M. F. (2019). Somatic hypermutation of T cell receptor gamma, delta, and beta chains in nurse sharks. Journal of Immunology. 202(1),
- Ott, J. A., Castro, C., Deiss, T., Ota, Y., Flajnik, M. F., & Criscitiello, M. F. (2018). Somatic hypermutation of TCR alpha contributes to thymic positive selection in sharks. Journal of Immunology. 200(1),
- Breaux, B. L., Hunter, M. E., Cruz-Schneider, M. P., Sena, L., Bonde, R. K., & Criscitiello, M. F. (2018). The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V segment locus synteny and chain-specific evolution. Journal of Immunology. 200(1),
Institutional Repository Documents1
- Ghaffari, N., Sanchez-Flores, A., Doan, R., Garcia-Orozco, K. D., Chen, P. L., Ochoa-Leyva, A., ... Criscitiello, M. F. (2014). Novel transcriptome assembly and improved annotation of the whiteleg shrimp (Litopenaeus vannamei), a dominant crustacean in global seafood mariculture. SCIENTIFIC REPORTS.
- Evolution of Immune Loci Critical in Antigen Recognition awarded by National Science Foundation 2013 - 2017
- Seelye, Stacie Lynn (2016-05). Genomic Organization of Zebrafish (Danio rerio) T Cell Receptor ?/? Locus and Analysis of Expressed Products. (Master's Thesis)
- Jacobs, Natalie Jo (2015-12). Why Maintain Light Chain Isotypes? The Influence of Heavy Chain Isotype and Complementary Determining Region Lengths upon Light Chain Isotype in Xenopus laevis. (Master's Thesis)
- Mashoof, Sara (2014-05). Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T. (Doctoral Dissertation)