- Associate Professor and Associate Department Head, Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences
My Comparative Immunogenetics Laboratory studies immunology, molecular genetics and evolution. Most of our group's research focuses on the natural history and future application of the vertebrate adaptive immune system, with particular attention given to the genetics of lymphocyte antigen receptors. Particular expertise lies in the evolution of vertebrate immunoglobulin loci, T cell receptor loci and the major histocompatibility complex. Additionally, we are interested in the evolution of diversification mechanisms at work there (e.g., recombination activating genes (RAG), activation-induced cytidine deaminase (AID), and the high allelic polymorphism maintained by classical MHC genes). Most recently, we have been working on lymphocyte development in shark thymus that suggests plasticity across the B lymphocyte/T lymphocyte divide, immunoglobulin heavy and light chain isotype pairing in an amphibian system, immunogenetics in marine mammals of conservation importance, mucosal humoral immunity in diverse tetrapods and cattle antibodies with an unheralded domain extending for novel antigen binding possibilities.
- Ph.D. in Microbiology and Immunology, University of Miami - (Coral Gables, Florida, United States) 2003
- M.S. in Molecular Biology, East Carolina University - (Greenville, North Carolina, United States) 1997
- B.S. in Biology, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 1993
- Deiss, T. C., Breaux, B., Ott, J. A., Daniel, R. A., Chen, P. L., Castro, C. D., ... Criscitiello, M. F. (2019). Ancient Use of Ig Variable Domains Contributes Significantly to the TCR delta Repertoire. JOURNAL OF IMMUNOLOGY. 203(5), 1265-1275.
- Abernath, K., Banach, M., Barela Hudgell, M. A., Blackmon, L. E., Breaux, B., Brusch, G. A., ... Yaparla, A. (2019). Conference report: The 14th congress of the International Society of Developmental and Comparative Immunology.. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 96, 83-92.
- Criscitiello, M. F., Kraev, I., & Lange, S. (2019). Deiminated proteins in extracellular vesicles and plasma of nurse shark (Ginglymostoma cirratum) - Novel insights into shark immunity.. Fish and Shellfish Immunology. 92, 249-255.
- Lujan, H., Criscitiello, M. F., Hering, A. S., & Sayes, C. M. (2019). Refining In Vitro Toxicity Models: Comparing Baseline Characteristics of Lung Cell-Types.. Toxicol Sci.
- Alves de Sa, A. L., Breaux, B., Tortola Burlamaqui, T. C., Deiss, T. C., Sena, L., Criscitiello, M. F., & Cruz Schneider, M. P. (2019). The Marine Mammal Class II Major Histocompatibility Complex Organization. Frontiers in Immunology. 10,
- Ott, J. A., Castro, C., Deiss, T., Ota, Y., Flajnik, M. F., & Criscitiello, M. F. (2018). Somatic hypermutation of TCR alpha contributes to thymic positive selection in sharks. JOURNAL OF IMMUNOLOGY. 200(1),
- Breaux, B. L., Hunter, M. E., Cruz-Schneider, M. P., Sena, L., Bonde, R. K., & Criscitiello, M. F. (2018). The Florida manatee (Trichechus manatus latirostris) T cell receptor loci exhibit V segment locus synteny and chain-specific evolution. JOURNAL OF IMMUNOLOGY. 200(1),
- Young, M., Li, E. S., Branham, E., Browne, Z., Koufteros, C. A., Pham, S., ... Criscitiello, M. F. (2016). Investigating distinct immunization routes in zebrafish on mucosal immunity. JOURNAL OF IMMUNOLOGY. 196,
- Ghaffari, N., Arshad, O. A., Jeong, H., Thiltges, J., Criscitiello, M. F., Yoon, B. J., Datta, A., & Johnson, C. D. (2014). De novo transcriptome assemblies and annotation for pacifie whiteleg shrimp. 1342-1343.
- Wei, Y., Mashoof, S., Cheruku, P., Zhuang, G., Bazer, F. W., Wu, G., ... Zhou, B. (2013). A Novel Paradigm of MicroRNA Regulation of Insulin Resistance: miR-150 Regulates Insulin Sensitivity Through Controlling B Cell Functions. DIABETES. 62, A75-A75.
- Seelye, Stacie Lynn (2016-05). Genomic Organization of Zebrafish (Danio rerio) T Cell Receptor ?/? Locus and Analysis of Expressed Products. (Master's Thesis)
- Jacobs, Natalie Jo (2015-12). Why Maintain Light Chain Isotypes? The Influence of Heavy Chain Isotype and Complementary Determining Region Lengths upon Light Chain Isotype in Xenopus laevis. (Master's Thesis)
- Mashoof, Sara (2014-05). Evolution of Mucosal Immunoglobulins: Xenopus Laevis IgX and Thunnus Orientalis IgZ/T. (Doctoral Dissertation)