My lab studies inner ear development in zebrafish. A prominent feature of our research is to investigate how cell-cell signaling and downstream gene-interactions control development. One project in the lab focuses on how cell signaling regulates ectodermal patterning during gastrulation to establish the otic placode, the precursor of the inner ear. Our recent work shows that localized Fgf signaling is especially critical for inducing formation of the otic placode, and members of the Pax2/5/8 family of transcription factors are important mediators of Fgf signaling. During later stages of inner ear development, we are exploring how sensory hair cells and neurons are regulated. Our studies address how these cells initially form, how they are genetically maintained, and how they become specialized for hearing vs. balance. We are also investigating how zebrafish can replace dead and damaged hair cells, an ability that mammals have lost. The inability to regenerate hair cells explains why humans show progressive irreversible hearing loss as we age. It is hoped that activating or augmenting human homologs of genes shown to operate in zebrafish might help restore hearing and balance in humans.
- University of Utah - (Salt Lake City, Utah, United States), Postdoctoral Training 1992
- Ph.D. in Molecular Biology, University of Wisconsin - Madison - (Madison, Wisconsin, United States) 1990
- University of Wisconsin - Madison - (Madison, Wisconsin, United States), Postdoctoral Training 1990
- B.A. in Biology, University of Colorado Boulder - (Boulder, Colorado, United States) 1982
- Gou, Y., Vemaraju, S., Sweet, E. M., Kwon, H., & Riley, B. B. (2018). sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear. DEVELOPMENTAL BIOLOGY. 435(1), 73-83.
- Gou, Y., Guo, J., Maulding, K., & Riley, B. B. (2018). sox2 and sox3 cooperate to regulate otic/epibranchial placode induction in zebrafish. DEVELOPMENTAL BIOLOGY. 435(1), 84-95.
- Kantarci, H., Gerberding, A., & Riley, B. B. (2016). Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle. Proc Natl Acad Sci U S A. 113(44), e6840-e6848.
- Kantarci, H., Edlund, R. K., Groves, A. K., & Riley, B. B. (2015). Tfap2a Promotes Specification and Maturation of Neurons in the Inner Ear through Modulation of Bmp, Fgf and Notch Signaling. PLOS Genetics. 11(3), e1005037-e1005037.
- Maulding, K., Padanad, M. S., Dong, J., & Riley, B. B. (2014). Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish. Dev Dyn. 243(10), 1275-1285.
- Kantarci, Husniye (2017-08). Reverse and Forward Genetics Approaches Reveal the Gene Networks That Regulate Development of Inner Ear Neurons. (Doctoral Dissertation)
- Bhat, Neha 1985- (2013-05). Developmental Mechanisms Regulating Specification of Preplacodal Ectoderm and its Morphogenesis into Sensory Placodes in Zebrafish. (Doctoral Dissertation)
- Vemaraju, Shruti (2011-12). Neurosensory Development in the Zebrafish Inner Ear. (Doctoral Dissertation)
- Padanad, Mahesh (2011-08). The Role of Fgf and Its Downstream Effectors in Otic and Epibranchial Development in Zebrafish. (Doctoral Dissertation)
- Millimaki, Bonny Butler (2010-08). The Function and Genetic Interactions of Zebrafish atoh1 and sox2: Genes Involved in Hair Cell Development and Regeneration. (Doctoral Dissertation)