overview
My research is focused on fetal brain development, stem cells, microRNAs, and teratology. Our laboratory is interested in understanding the biological steps that transform uncommitted stem cells into neurons or a glial cells, and identifying key microRNAs that control the transformation of stem cells into neurons. We are also currently investigating what role teratogen-sensitive microRNAs play in fetal brain growth, and the spatial patterning of the emerging forebrain.
education and training
- Ph.D. in Psychology, University of Rochester - (Rochester, New York, United States) 1998
selected publications
Academic Articles94
- Salem, N. A., Mahnke, A. H., Konganti, K., Hillhouse, A. E., & Miranda, R. C. (2021). Cell-type and fetal-sex-specific targets of prenatal alcohol exposure in developing mouse cerebral cortex. iScience. 24(5), 102439-102439.
- Mahnke, A. H., Sideridis, G. D., Salem, N. A., Tseng, A. M., Carter, R. C., Dodge, N. C., ... Jacobson, J. L. (2021). Infant circulating MicroRNAs as biomarkers of effect in fetal alcohol spectrum disorders. SCIENTIFIC REPORTS. 11(1), 1429.
- Salem, N. A., Mahnke, A. H., Wells, A. B., Tseng, A. M., Yevtushok, L., Zymak-Zakutnya, N., ... Miranda, R. C. (2020). Association between fetal sex and maternal plasma microRNA responses to prenatal alcohol exposure: evidence from a birth outcome-stratified cohort. Biology of Sex Differences. 11(1), 51.
- Salem, N. A., Mahnke, A. H., Tseng, A. M., Garcia, C. R., Jahromi, H. K., Geoffroy, C. G., & Miranda, R. C. (2020). A novel Oct4/Pou5f1-like non-coding RNA controls neural maturation and mediates developmental effects of ethanol. Neurotoxicology and Teratology. 83, 106943-106943.
- Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V. (2020). Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure.. Journal of Biomedical Optics. 25(12),
Chapters6
- Mahnke, A. H., Salem, N. A., Tseng, A. M., Fincher, A. S., Klopfer, A., & Miranda, R. C. (2018). Fetal Alcohol Spectrum Disorders: A Stem‐Cellopathy?. Stem Cells in Birth Defects Research and Developmental Toxicology. (pp. 223-259). John Wiley & Sons, Inc.
- Tseng, A. M., Mahnke, A. H., Salem, N. A., & Miranda, R. C. (2018). Chapter 30 Noncoding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation Implications for Stem Cell Therapy. Epigenetics in Human Disease. (pp. 903-933). Elsevier.
- Miranda, R. C., Salem, N. A., Fincher, A. S., Mahnke, A. H., & Burrowes, S. G. (2016). Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease. Medical Epigenetics. (pp. 532-552). Elsevier.
- Miranda, R. C., & Balaraman, S. (2014). MicroRNAs in Alcohol Abuse and Toxicity. Neurobiology of Alcohol Dependence. (pp. 497-521). Elsevier.
- Miranda, R. C. (2012). Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy. Epigenetics in Human Disease. (pp. 503-518). Elsevier.
Conference Papers7
- Mahnke, A. H., Leeman, L., Luo, L., Abdelfattah, A., Shrestha, S., Miranda, R. C., & Bakhireva, L. N. (2019). Neonatal Cord Blood miRNAs As Biomarkers of Neonatal Opioid Withdrawal Syndrome. BIRTH DEFECTS RESEARCH. 111(9), 493-493.
- Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V. (2019). In utero optical coherence tomography reveals changes in murine embryonic brain vasculature after prenatal cannabinoid exposure. Progress in Biomedical Optics and Imaging. 10867, 108671x.
- Miranda, R. C. (2017). Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs). BIRTH DEFECTS RESEARCH. 109(9), 632-632.
- Raghunathan, R., Wu, C., Singh, M., Liu, C., Miranda, R. C., & Larin, K. V. (2017). Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography. SILICON PHOTONICS XIII. 10340, 103401g-103401g-1.
- Miranda, R. C. (2017). Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs). Neurotoxicology and Teratology. 61, 149-150.
researcher on
Principal Investigator5
Co-Principal Investigator3
Investigator2
- Epigenetics of the Aging Astrocyte: Implications for Stroke awarded by DHHS-NIH-National Institute On Aging 2018 - 2023
recent teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BIOT684 Direct Prof Internship: In-ab Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT684 Directed Prof Internship Instructor
chaired theses and dissertations
- Al Muhisen, Hadil Mahdi J (2018-08). Sex Differences in Fetal Neural Stem Cells' Response to Ethanol. (Master's Thesis)
- Raymond, Elizabeth S (2016-08). Effects of the Developmental Teratogens Ethanol and Nicotine on Long Noncoding RNA Expression in Mouse Fetal Neural Stem Cells of the Cortex. (Master's Thesis)
- Holgate, Rhonda Renay (2015-05). Ethanol Targeting nELAVs: Implications for Neural Stem Cell Maturation. (Doctoral Dissertation)
- Tsai, Pai Chi (2014-05). miR-153 and miR-335, Ethanol Sensitive MicroRNAs, Control NSC/NPC Maturation during Fetal Brain Development. (Doctoral Dissertation)
- Strickland, Eric (2013-08). MicroRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Neuropathic Pain. (Doctoral Dissertation)
Email
rmiranda@tamu.edu
First Name
Rajesh
Last Name
Miranda
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
College Station, TX 77843-1114
USA