overview
My research is focused on fetal brain development, stem cells, microRNAs, and teratology. Our laboratory is interested in understanding the biological steps that transform uncommitted stem cells into neurons or a glial cells, and identifying key microRNAs that control the transformation of stem cells into neurons. We are also currently investigating what role teratogen-sensitive microRNAs play in fetal brain growth, and the spatial patterning of the emerging forebrain.
selected publications
Academic Articles85
- Pinson, M. R., & Miranda, R. C. (2019). Noncoding RNAs in development and teratology, with focus on effects of cannabis, cocaine, nicotine, and ethanol. BIRTH DEFECTS RESEARCH. 111(17), 1308-1319.
- Raghunathan, R., Liu, C., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V. (2019). Assessing the acute effects of prenatal synthetic cannabinoid exposure on murine fetal brain vasculature using optical coherence tomography.. Journal of Biophotonics. 12(8), e201900050.
- Tseng, A. M., Chung, D. D., Pinson, M. R., Salem, N. A., Eaves, S. E., & Miranda, R. C. (2019). Ethanol Exposure Increases miR-140 in Extracellular Vesicles: Implications for Fetal Neural Stem Cell Proliferation and Maturation. Alcohol Clin Exp Res. 43(7), 1414-1426.
- Tseng, A. M., Mahnke, A. H., Wells, A. B., Salem, N. A., Allan, A. M., Roberts, V., ... Fetal, C. I. (2019). Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation. Life science alliance. 2(2), e201800252-e201800252.
- Mahnke, A. H., Adams, A. M., Wang, A. Z., & Miranda, R. C. (2019). Toxicant and teratogenic effects of prenatal alcohol. Current Opinion in Toxicology. 14, 29-34.
Chapters5
- Mahnke, A. H., Salem, N. A., Tseng, A. M., Fincher, A. S., Klopfer, A., & Miranda, R. C. (2018). Fetal Alcohol Spectrum Disorders: A Stem-Cellopathy?. Stem Cells in Birth Defects Research and Developmental Toxicology. (pp. 223-259). John Wiley & Sons, Inc.
- Miranda, R. C., Salem, N. A., Fincher, A. S., Mahnke, A. H., & Burrowes, S. G. (2016). Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease. Medical Epigenetics. (pp. 532-552). Elsevier.
- Miranda, R. C., & Balaraman, S. (2014). MicroRNAs in Alcohol Abuse and Toxicity. Neurobiology of Alcohol Dependence. (pp. 497-521). Elsevier.
- Miranda, R. C. (2012). Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy. Epigenetics in Human Disease. (pp. 503-518). Elsevier.
- Miranda, R. C., & Sohrabji, F. (1996). Gonadal steroid receptors: Possible roles in the etiology and therapy of cognitive and neurological disorders. Annual Reports in Medicinal Chemistry. (pp. 11-20). Elsevier.
Conference Papers7
- Mahnke, A. H., Leeman, L., Luo, L., Abdelfattah, A., Shrestha, S., Miranda, R. C., & Bakhireva, L. N. (2019). Neonatal Cord Blood miRNAs As Biomarkers of Neonatal Opioid Withdrawal Syndrome. BIRTH DEFECTS RESEARCH. 111(9), 493-493.
- Raghunathan, R., Liu, C. H., Kouka, A., Singh, M., Miranda, R. C., & Larin, K. V. (2019). In utero optical coherence tomography reveals changes in murine embryonic brain vasculature after prenatal cannabinoid exposure. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 10867,
- Raghunathan, R., Wu, C., Singh, M., Nguyen, J., Liu, C. H., Miranda, R. C., & Larin, K. V. (2018). In utero optical coherence tomography to evaluate vasculature changes in the murine embryonic brain due to prenatal Alcohol and Nicotine exposure. 610.
- Miranda, R. C. (2017). Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs). BIRTH DEFECTS RESEARCH. 109(9), 632-632.
- Raghunathan, R., Wu, C., Singh, M., Liu, C. H., Miranda, R. C., & Larin, K. V. (2017). Evaluating changes in brain vasculature of murine embryos in utero due to maternal alcohol consumption using optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 10340,
teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- BIOT684 Direct Prof Internship: In-ab Instructor
- BIOT684 Directed Pro Internship: In-ab Instructor
- BIOT684 Directed Prof Intern: In-ab Instructor
chaired theses and dissertations
- Al Muhisen, Hadil Mahdi J (2018-08). Sex Differences in Fetal Neural Stem Cells' Response to Ethanol. (Master's Thesis)
- Raymond, Elizabeth S (2016-08). Effects of the Developmental Teratogens Ethanol and Nicotine on Long Noncoding RNA Expression in Mouse Fetal Neural Stem Cells of the Cortex. (Master's Thesis)
- Holgate, Rhonda Renay (2015-05). Ethanol Targeting nELAVs: Implications for Neural Stem Cell Maturation. (Doctoral Dissertation)
- Tsai, Pai Chi (2014-05). miR-153 and miR-335, Ethanol Sensitive MicroRNAs, Control NSC/NPC Maturation during Fetal Brain Development. (Doctoral Dissertation)
- Strickland, Eric (2013-08). MicroRNA Dysregulation Following Spinal Cord Contusion: Implications for Neural Plasticity and Neuropathic Pain. (Doctoral Dissertation)
Email
rmiranda@tamu.edu
First Name
Rajesh
Last Name
Miranda
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
College Station, TX 77843-1114
USA