Samuel, James individual record
Regents Professor and Head
Positions:
overview

Our laboratory works with the obligate intracellular bacterial pathogen, Coxiella burnetii, the etiologic agent of Q fever and a category B biothreat agent. The long-term goal of this research is to understand the molecular pathogenic mechanisms involved in the host-pathogen interaction. To accomplish this broad goal, project in the lab are designed to test the molecular mechanisms employed by both the host and pathogen. Current pathogen studies include 1) broad survey of proteins secreted via a type 4 secretion system (T4SS) followed by determination of essentiality of each substrate for virulence and detailed analysis of mechanism of host modulation 2) survey of essential virulence loci identified by specific mutant screens, and 3) definition of the relative virulence of phylogenetically distinct isolate groups.

selected publications
Academic Articles102
  • Gregory, A. E., van Schaik, E. J., Fratzke, A. P., Russell-Lodrigue, K. E., Farris, C. M., & Samuel, J. E. (2021). Soluble antigens derived from Coxiella burnetii elicit protective immunity in three animal models without inducing hypersensitivity. Cell Reports Medicine. 2(12), 100461-100461.
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  • Fratzke, A. P., Gregory, A. E., van Schaik, E. J., & Samuel, J. E. (2021). Coxiella burnetii Whole Cell Vaccine Produces a Th1 Delayed-Type Hypersensitivity Response in a Novel Sensitized Mouse Model. Frontiers in Immunology. 12, 754712.
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  • Ouyang, Y., Chen, D., Fu, Y., Shi, W., Provin, T., Han, A., ... Zhou, J. (2021). Direct cell extraction from fresh and stored soil samples: Impact on microbial viability and community compositions. Soil Biology and Biochemistry. 155, 108178-108178.
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  • Fratzke, A. P., Jan, S., Felgner, J., Liang, L. i., Nakajima, R., Jasinskas, A., ... Gregory, A. E. (2021). Subunit Vaccines Using TLR Triagonist Combination Adjuvants Provide Protection Against Coxiella burnetii While Minimizing Reactogenic Responses.. Front Immunol. 12, 653092.
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  • Chen, C., van Schaik, E. J., Gregory, A. E., Vigil, A., Felgner, P. L., Hendrix, L. R., Faris, R., & Samuel, J. E. (2019). Chemokine Receptor 7 Is Essential for Coxiella burnetii Whole-Cell Vaccine-Induced Cellular Immunity but Dispensable for Vaccine-Mediated Protective Immunity.. J Infect Dis. 220(4), 624-634.
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Chapters2
  • Toman, R., Heinzen, R. A., Samuel, J. E., & Mege, J. (2012). Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium Preface. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. COXIELLA BURNETII: RECENT ADVANCES AND NEW PERSPECTIVES IN RESEARCH OF THE Q FEVER BACTERIUM. V-XI.
  • Mertens, K., & Samuel, J. E. (2007). Bacteriology of coxiella. Rickettsial Diseases. 257-270.
Conference Papers2
  • TESH, V. L., SAMUEL, J. E., BURRIS, J. A., OWENS, J. W., TAYLOR, F. B., & SIEGLER, R. L. (1994). QUANTITATION AND LOCALIZATION OF SHIGA TOXIN SHIGA-LIKE TOXIN-BINDING GLYCOLIPID RECEPTORS IN HUMAN AND BABOON TISSUES. RECENT ADVANCES IN VEROCYTOTOXIN-PRODUCING ESCHERICHIA COLI INFECTIONS. 1072, 189-192.
  • Frazier, M. E., Mallavia, L. P., Samuel, J. E., & Baca, O. G. (1990). DNA probes for the identification of Coxiella burnetti strains.. Ann N Y Acad Sci. 590(1 Rickettsiolog), 445-458.
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patents
Patents1
  • Samuel, J. E., Van, S., & Gregory, A. E. (2021). Vaccine for immunization against Q-fever.
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chaired theses and dissertations
Email
jsamuel@tamu.edu
First Name
James
Last Name
Samuel
mailing address
Texas A&M Health Science Center; Microbial Pathogenesis And Immunology; 1114 TAMUS
College Station, TX 77843-1114
USA