Scholars

Samuel, James

Regents Professor and Head

Positions:

Regents Professor and Head, Microbial Pathogenesis and Immunology, College of Medicine

Single Page Bio

jsamuel@tamu.edu

1 979 862 1684

Co-author Network

Map of Science

Websites

Samuel Lab Website

overview

Our laboratory works with the obligate intracellular bacterial pathogen, Coxiella burnetii, the etiologic agent of Q fever and a category B biothreat agent. The long-term goal of this research is to understand the molecular pathogenic mechanisms involved in the host-pathogen interaction. To accomplish this broad goal, project in the lab are designed to test the molecular mechanisms employed by both the host and pathogen. Current pathogen studies include 1) broad survey of proteins secreted via a type 4 secretion system (T4SS) followed by determination of essentiality of each substrate for virulence and detailed analysis of mechanism of host modulation 2) survey of essential virulence loci identified by specific mutant screens, and 3) definition of the relative virulence of phylogenetically distinct isolate groups.

education and training

Uniformed Services University of the Health Sciences - (Bethesda, Maryland, United States), Postdoctoral Training 1990
Ph.D. in Microbiology, Washington State University - (Pullman, Washington, United States) 1986
M.S. in Biology, Washington State University - (Pullman, Washington, United States) 1983
B.A. in Zoology and Chemistry, Miami University - (Oxford, Ohio, United States) 1976

selected publications

Academic Articles102

Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Samuel, J., & Arenas-Gamboa, A. M. (2019). Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs. PLoS ONE. 14(3), e0212457-e0212457.
Hensel, M. E., Garcia-Gonzalez, D. G., Chaki, S. P., Samuel, J., & Arenas-Gamboa, A. M. (2019). Characterization of an intratracheal aerosol challenge model of Brucella melitensis in guinea pigs (vol 14, e0212457, 2019). PLoS ONE. 14(6), e0218065-e0218065.
Chen, C., van Schaik, E. J., Gregory, A. E., Vigil, A., Felgner, P. L., Hendrix, L. R., Faris, R., & Samuel, J. E. (2019). Chemokine Receptor 7 Is Essential for Coxiella burnetii Whole-Cell Vaccine-Induced Cellular Immunity but Dispensable for Vaccine-Mediated Protective Immunity. The Journal of infectious diseases. 220(4), 624-634.
Gregory, A. E., van Schaik, E. J., Russell-Lodrigue, K. E., Fratzke, A. P., & Samuel, J. E. (2019). Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates. INFECTION AND IMMUNITY. 87(12),
Weber, M. M., Faris, R., van Schaik, E. J., & Samuel, J. E. (2018). Identification and characterization of arginine finger-like motifs, and endosome-lysosome basolateral sorting signals within the Coxiella burnetii type IV secreted effector protein CirA. MICROBES AND INFECTION. 20(5), 302-307.

Chapters2

Toman, R., Heinzen, R. A., Samuel, J. E., & Mege, J. (2012). Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium Preface. MATHEMATICAL MODELLING IN EXPERIMENTAL NUTRITION. COXIELLA BURNETII: RECENT ADVANCES AND NEW PERSPECTIVES IN RESEARCH OF THE Q FEVER BACTERIUM. (pp. V-XI).
Mertens, K., & Samuel, J. E. (2007). Bacteriology of coxiella. Rickettsial Diseases. (pp. 257-270).

Conference Papers2

TESH, V. L., SAMUEL, J. E., BURRIS, J. A., OWENS, J. W., TAYLOR, F. B., & SIEGLER, R. L. (1994). QUANTITATION AND LOCALIZATION OF SHIGA TOXIN SHIGA-LIKE TOXIN-BINDING GLYCOLIPID RECEPTORS IN HUMAN AND BABOON TISSUES. ANIMALS AND ENVIRONMENTS. 1072, 189-192.
Frazier, M. E., Mallavia, L. P., Samuel, J. E., & Baca, O. G. (1990). DNA probes for the identification of Coxiella burnetti strains.. TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY. 590(1), 445-458.