Dr Svoboda is a well-established senior principal investigator with a broad background in developmental biology and cellular biology. Her research focus is on the cell biology of whole embryonic tissues, including cornea, cartilage, palate. Her lab has been funded from NIH, March of Dimes, Foundations and Private Companies for 3 decades. As a postdoctoral fellow at Harvard Medical School, she carried out cell and molecular biology experiments on developing systems and worked with Dr. Elizabeth Hay when she developed her theories on cell-matrix interactions. As PI or co-Investigator on many previous university- and March of Dimes funded grants (over 30 years of continuous funding), she worked on how cell-matrix interactions change during development. In addition, she was a mentor on two training grants (T32 and KL2) and has successfully administered other NIH supported developmental and cell biology projects (e.g. staffing, research protections, and budget), collaborated with other researchers, and produced peer-reviewed publications from each project.
She has a new project that contributes evidence to the theory that periocular mesenchyme (POM) cells contribute to the development of the ciliary body, trabecular meshwork and the iridocorneal angle. The objective of this project is to determine if Gli1 positive cells contribute to the POM and anterior eye structures by using inducible Gli1-CreERT2; tdTomatoflox (Gli1-tdTomato) mouse model. Experiments were recently completed that demonstrated the Gli1 + cells were also positive for Pitx2, FOXC1, and FOXC2, known markers for periocular mesenchyme during anterior eye development.
She has successfully trained 40 Postdoctoral, Ph.D., M.S. graduate students, undergraduate, medical and dental predoctoral students, and college/high school summer research trainees.
- Ph.D. in Anatomy, University of Nebraska at Omaha - (Omaha, Nebraska, United States) 1982
- M.S. in Human Genetics, University of Nebraska Medical Center - (Omaha, Nebraska, United States) 1979
- B.S. in Biology, University of Nebraska at Omaha - (Omaha, Nebraska, United States) 1974
- DeSantis-Rodrigues, A., Hahn, R. A., Zhou, P., Babin, M., Svoboda, K., Chang, Y., Gerecke, D. R., & Gordon, M. K. (2021). SM1997 downregulates mustard‐induced enzymes that disrupt corneal epithelial attachment. Anat Rec (Hoboken). 304(9), 1974-1983.
- Taylor, R. W., Mitchell, G. K., Andrade, J. L., & Svoboda, K. K. (2020). Expression of Collagen Types I, II, IX, and X in the Mineralizing Turkey Gastrocnemius Tendon.. Anat Rec (Hoboken). 303(6), 1664-1669.
- Logan, S. M., Ruest, L. B., Benson, M. D., & Svoboda, K. (2020). Extracellular Matrix in Secondary Palate Development.. Anat Rec (Hoboken). 303(6), 1543-1556.
- Svoboda, K., & Gordon, M. K. (2020). Extracellular matrix: The proteins that function throughout the body.. Anat Rec (Hoboken). 303(6), 1509-1513.
- Chang, B., Svoboda, K., & Liu, X. (2019). Cell polarization: From epithelial cells to odontoblasts.. Eur J Cell Biol. 98(1), 1-11.
- Liu, X., Qu, T., Sachar, A., & Svoboda, K. (2015). Cell-Matrix Interactions and Signal Transduction. Elsevier.
- Hirsch, M. S., & Svoboda, K. K. (1996). Beta 1 integrin antibodies inhibit chondrocyte terminal differentiation in whole sterna.. Wiley.
- Svoboda, K. K., Thomson, R., & Zhao, H. K. (2020). Timed Induction of Gli1 (P3 To P30) Was Expressed In Mouse Trabecular Meshwork. The FASEB Journal. 34(S1), 1-1.
- Maciejewska, I., Qin, D., Huang, B., Sun, Y., Mues, G., Svoboda, K., ... Qin, C. (2009). Distinct compartmentalization of dentin matrix protein 1 fragments in mineralized tissues and cells.. Cells Tissues Organs. 189(1-4), 186-191.
- Nares, S., DeLeon, C., Kuba, R., Albright, G. M., Svoboda, K. K., & Iacopino, A. M. (1999). Macrophage morphology and migration are influenced by ECM substrate. MOLECULAR BIOLOGY OF THE CELL. 10, 346A-346A.
- Ibrahim, Isra (2015-05). Decorin and Biglycan Expression and Distribution during Palatal Shelf Adhesion. (Master's Thesis)
- Serrano, Maria Juliana (2015-05). EPH and Ephrins in Palate Development. (Doctoral Dissertation)
- Beltran, Stacy Renay (2014-05). Anti-inflammatory Protein TSG-6 Promotes Early Gingival Wound Healing: An In Vivo Study. (Master's Thesis)