DeMorrow, Sharon individual record
Associate Professor
Positions:
overview

My research broadly focuses on the factors controlling hyperplastic and neoplastic cholangiocyte proliferation. Cholangiocytes are the epithelial cells that line in the intra- and extra-hepatic bile ducts and that are responsible for the modification of ductal bile.; These cells are the target of cholestatic liver diseases such as primary biliary cirrhosis and primary sclerosing cholangitis, and are characterized by cholangiocyte proliferation and/or loss. This class of liver disease represents the first major indicator for liver transplantation in children and the third major indicator in adults. The neoplastic transformation of cholangiocytes into the malignant counterpart gives rise to cholangiocarcinoma, which has very few effective treatment options and poor prognosis. Thus, factors that affect the hyperplastic and neoplastic cholangiocyte proliferation may lead to novel treatment paradigms.

selected publications
Academic Articles103
Chapters3
  • DeMorrow, S., Francis, H., Marzioni, M., Leyva-Illades, D., Han, Y., & Alpini, G. (2014). Cholangiocarcinoma. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. (pp. 1894-1911).
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  • Demorrow, S., & Butterworth, R. F. (2014). Hepatic encephalopathy: A primary neurogliopathy. Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. (pp. 351-372).
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  • Alpini, G., & DeMorrow, S. (2009). CHANGES IN THE ENDOCANNABINOID SYSTEM MAY GIVE INSIGHT INTO NEW AND EFFECTIVE TREATMENTS FOR CANCER. FOLIC ACID AND FOLATES. VITAMINS AND HORMONES: ANANDAMIDE AN ENDOGENOUS CANNABINOID. (pp. 469-485). Elsevier.
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recent teaching activities
chaired theses and dissertations
Email
demorrow@tamu.edu
First Name
Sharon
Last Name
DeMorrow
mailing address
Texas A&M Health Science Center; Internal Medicine - Scott And White; 1114 TAMUS
Temple, TX 76504
USA