Hettema, John individual record
  • Professor

I am Professor in the Department of Psychiatry at Texas A&M Health Sciences Center and affiliate faculty member at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). As a clinician-scientist, I have participate in patient care, clinical teaching, and research activities. Before coming to TAMU in 2019, I directed the VCU Anxiety Disorders Specialty Clinic for 19 years, providing residency training and patient care via the assessment and treatment of all the major anxiety and related disorders. My research efforts focus on the epidemiology, genetics, and biology of the anxiety and related internalizing disorders. I have extensive experience applying advanced statistical genetic methodology to these questions via analyses conducted in twin, family, and population-based samples. My recent projects include conducting meta-analyses of genomewide association data on anxiety spectrum disorders (ANGST GWAS project, R01MH087646 and PGC-ANX project, R01MH113665), examining the effects of novel candidate genes derived from GWAS on internalizing psychopathology (R01MH039096), and collecting and analyzing endophenotypic measures underlying the development of internalizing disorders in a juvenile twin sample (R01MH098055). My research has been funded by NIH and private foundation grants. I am founding co-chair of the PGC-ANX Working Group which provides active collaborations with anxiety and depression researchers around the world.

selected publications
Academic Articles75
  • Ma, L., Hettema, J. M., Cousijn, J., Bjork, J. M., Steinberg, J. L., Keyser-Marcus, L., ... Moeller, F. G. (2021). Resting-State Directional Connectivity and Anxiety and Depression Symptoms in Adult Cannabis Users.. Biol Psychiatry Cogn Neurosci Neuroimaging. 6(5), 545-555.
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  • Lisdahl, K. M., Tapert, S., Sher, K. J., Gonzalez, R., Nixon, S. J., Feldstein Ewing, S. W., ... ABCD Consortium. (2021). Substance use patterns in 9-10 year olds: Baseline findings from the adolescent brain cognitive development (ABCD) study.. Drug Alcohol Depend.
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  • Rappaport, L. M., Carney, D. M., Brotman, M. A., Leibenluft, E., Pine, D. S., Roberson-Nay, R., & Hettema, J. M. (2020). A Population-Based Twin Study of Childhood Irritability and Internalizing Syndromes.. J Clin Child Adolesc Psychol. 49(4), 524-534.
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  • Hettema, J. M., Bourdon, J. L., Sawyers, C., Verhulst, B., Brotman, M. A., Leibenluft, E., Pine, D. S., & Roberson-Nay, R (2020). Genetic and environmental risk structure of internalizing psychopathology in youth.. Depress Anxiety. 37(6), 540-548.
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  • Kramer, M. D., Patrick, C. J., Hettema, J. M., Moore, A. A., Sawyers, C. K., & Yancey, J. R. (2020). Quantifying Dispositional Fear as Threat Sensitivity: Development and Initial Validation of a Model-Based Scale Measure.. Assessment. 27(3), 533-546.
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  • Hettema, J. M. (2015). The Etiology of Fear and Anxiety. Anxiety Disorders. 189-200. Oxford University Press.
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  • Perez, J. A., Otowa, T., Roberson-Nay, R., & Hettema, J. M. (2013). Genetics of Anxiety Disorders. Ressler, K. J. (Eds.), Neurobiology of Mental Illness. 537-546. Oxford University Press.
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  • Maron, E., Hettema, J. M., & Shlik, J. (2008). Chapter 5.6 The genetics of human anxiety disorders. Handbook of Behavioral Neuroscience. Handbook of Anxiety and Fear. 475-510. Elsevier.
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Conference Papers11
  • Ask, H., Eilertsen, E. M., Gustavson, K., McAdams, T., Torvik, F. A., Hettema, J. M., ... Ystrom, E. (2019). Intergenerational transmission of parental neuroticism to offspring neuroticism, anxiety, and depression. BEHAVIOR GENETICS. 49(6), 548-548.
  • Neale, M. C., Andrews, P. W., & Hettema, J. M. (2008). Maximum Likelihood Estimation of Genetic, Environmental and Phenotypic Factor Scores. BEHAVIOR GENETICS. 38(6), 640-640.
  • Hettema, J. M., An, S., Neale, M. C., Van den Oord, E. J., Kendler, K. S., & Chen, X. (2006). Genetic association study of the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders. NEUROPSYCHOPHARMACOLOGY. 31, S167-S167.
  • Hettema, J. M., An, S. S., Neale, M. C., Bukszar, J., van den Oord, E., Kendler, K. S., & Chen, X. (2006). Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism.. Mol Psychiatry. 11(8), 752-762.
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  • Hettema, J. M., Neale, M. C., Myers, J. M., Prescott, C. A., & Kendler, K. S. (2006). A population-based twin study of the relationship between neuroticism and internalizing disorders.. Am J Psychiatry. 163(5), 857-864.
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Repository Documents / Preprints1
  • Purves, K. L., Coleman, J., Meier, S. M., Rayner, C., Davis, K., Cheesman, R., ... Eley, T. C. (2017). A Major Role for Common Genetic Variation in Anxiety Disorders.
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