Sczepanski, Jonathan individual record
Assistant Professor

Our primary research goals are to develop and apply novel tools for studying DNA damage in the context of chromatin and to explore new avenues for RNA-based therapeutics and diagnostics. By combining expertise in chemical biology, molecular biology, and molecular evolution, our lab addresses challenges associated with studying and targeting noncoding RNAs from a unique perspective. In addition, we utilize modern chemical biology techniques to develop designer chromatin systems for studying DNA damage. We are seeking motivated individuals who wish to gain experience in chemical biology, molecular biology, and in vitro evolution techniques.

selected publications
Academic Articles25
  • Kabza, A. M., & Sczepanski, J. T. (2020). l-DNA-Based Catalytic Hairpin Assembly Circuit. 25(4), 947-947.
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  • Tjhung, K. F., Sczepanski, J. T., Murtfeldt, E. R., & Joyce, G. F. (2020). RNA-Catalyzed Cross-Chiral Polymerization of RNA. 142(36), 15331-15339.
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  • Dey, S., & Sczepanski, J. T. (2020). In vitro selection of l-DNA aptamers that bind a structured d-RNA molecule. 48(4), 1669-1680.
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  • Banerjee, D. R., Deckard, C. E., Zeng, Y. u., & Sczepanski, J. T. (2019). Acetylation of the histone H3 tail domain regulates base excision repair on higher-order chromatin structures. 9(1), 15972.
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Conference Papers4
  • Zhou, C., Sczepanski, J. T., & Greenberg, M. M (2012). Rapid DNA strand scission at a basic sites in nucleosome core particles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 244,
  • Sczepanski, J. T., & Joyce, G. F (2012). Synthesis and evolution of genetically encoded cross-replicating ribozymes. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 243,
  • Sczepanski, J., Jacobs, A., Van Houten, B., & Greenberg, M. M (2010). Scope and Mechanism of Formation of Interstrand Cross-Links That Give Rise to Double Strand Breaks upon Nucleotide Excision Repair. CHEMICAL RESEARCH IN TOXICOLOGY. 23(1), 284-284.
  • Sczepanski, J., Jacobs, A., & Greenberg, M. M ORGN 114-Interstrand cross-link (ICL) formation by the C4'-oxidized abasic site in DNA. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 236,
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Texas A&M University; Chemistry; 3255 TAMU
College Station, TX 77843-3255