The long-term objective of my research is to identify and characterized virulence determinants that contribute to the pathogenic potential of the B. burgdorferi. Through the utilization of in vivo bioluminescence we are evaluating the kinetics of borrelial infectivity in various strains or mutant derivatives that exhibit distinct phenotypes. We are also tracking how in vivo synthesis of critical virulence determinants affects B. burgdorferi colonization and dissemination. This work will contribute to the current body of knowledge by shedding light on the pathogenic and temporal role of specific borrelial genes during the infectious process.
- Texas A&M Health Science Center - (College Station, Texas, United States), Postdoctoral Training 2010
- Ph.D. in Medical Sciences, Texas A&M Health Science Center - (College Station, Texas, United States) 2005
- B.S. in Microbiology, Texas A&M University - (College Station, Texas, United States) 1996
- Phelan, J. P., Kern, A., Ramsey, M. E., Lundt, M. E., Sharma, B., Lin, T., ... Hu, L. T. (2019). Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector.. PLoS pathogens. 15(5), e1007644-e1007644.
- Ramsey, M. E., Hyde, J. A., Medina-Perez, D. N., Lin, T., Gao, L., Lundt, M. E., ... Hu, L. T. (2017). A high-throughput genetic screen identifies previously uncharacterized Borrelia burgdorferi genes important for resistance against reactive oxygen and nitrogen species. PLoS pathogens. 13(2), e1006225-e1006225.
- Hyde, J. A. (2017). Borrelia burgdorferi keeps moving and carries on: A review of borrelial dissemination and invasion. Frontiers in Immunology. 8(FEB), 114.
- Skare, J. T., Shaw, D. K., Trzeciakowski, J. P., & Hyde, J. A. (2016). In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection. PLoS ONE. 11(9), e0162501-e0162501.
- Zhi, H., Weening, E. H., Barbu, E. M., Hyde, J. A., Hoeoek, M., & Skare, J. T. (2015). The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis. Mol Microbiol. 96(1), 68-83.