The long-term objective of my research is to identify and characterized virulence determinants that contribute to the pathogenic potential of the B. burgdorferi. Through the utilization of in vivo bioluminescence we are evaluating the kinetics of borrelial infectivity in various strains or mutant derivatives that exhibit distinct phenotypes. We are also tracking how in vivo synthesis of critical virulence determinants affects B. burgdorferi colonization and dissemination. This work will contribute to the current body of knowledge by shedding light on the pathogenic and temporal role of specific borrelial genes during the infectious process.
- Texas A&M Health Science Center - (College Station, Texas, United States), Postdoctoral Training 2010
- Ph.D. in Medical Sciences, Texas A&M Health Science Center - (College Station, Texas, United States) 2005
- B.S. in Microbiology, Texas A&M University - (College Station, Texas, United States) 1996
- Phelan, J. P., Kern, A., Ramsey, M. E., Lundt, M. E., Sharma, B., Lin, T., ... Hu, L. T. (2019). Genome-wide screen identifies novel genes required for Borrelia burgdorferi survival in its Ixodes tick vector. PLoS pathogens. 15(5), e1007644-e1007644.
- Hyde, J. A. (2017). Borrelia burgdorferi Keeps Moving and Carries on: A Review of Borrelial Dissemination and Invasion. Frontiers in Immunology. 8(FEB), 114.
- Zhi, H., Weening, E. H., Barbu, E. M., Hyde, J. A., Hoeoek, M., & Skare, J. T. (2015). The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis. Mol Microbiol. 96(1), 68-83.
- Gilmore, R. D., Brandt, K. S., & Hyde, J. A. (2014). pncA and bptA Are Not Sufficient To Complement Ixodes scapularis Colonization and Persistence by Borrelia burgdorferi in a Linear Plasmid lp25-Deficient Background. INFECTION AND IMMUNITY. 82(12), 5110-5116.
- Shaw, D. K., Hyde, J. A., & Skare, J. T. (2012). The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease. Mol Microbiol. 83(2), 319-334.
- Hyde, J. A., & Skare, J. T. (2018). Detection of Bioluminescent Borrelia burgdorferi from In Vitro Cultivation and During Murine Infection.. Methods in molecular biology (Clifton, N.J.). Methods in Molecular Biology. (pp. 241-257). Springer New York.