Our research interest is biomolecular engineering for applications in health, agriculture, and energy. The research themes include discovery of biological molecules involved in microbe- and host-microbe interactions, elucidating the biosynthesis of bioactive molecules, and harnessing the knowledge to design bio-based systems for diagnostics and treatment. To advance our research, we use principles in microbiology, molecular biology, biochemistry, analytical chemistry, protein engineering, metabolic engineering, as well as emerging tools in chemical biology and synthetic biology.
- Zhu, X., Su, M., Manickam, K., & Zhang, W. (2015). Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis. ACS Chemical Biology. 10(12), 2785-2793.
- Zhu, X., Liu, J., & Zhang, W. (2015). De novo biosynthesis of terminal alkyne-labeled natural products. Nature Chemical Biology. 11(2), 115-120.
- Zhu, X., Shieh, P., Su, M., Bertozzi, C. R., & Zhang, W. A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chemical Communications. 52(75), 11239-11242.
- Zhu, X., & Zhang, W. Tagging polyketides/non-ribosomal peptides with a clickable functionality and applications. FRONTIERS IN CHEMISTRY. 3,