Tong, Carl
individual record
Associate Professor
Positions:
- Associate Professor, Medical Physiology, School of Medicine
overview
Cardiovascular disease remains as the number one cause of mortality. About 50% of heart failure patients will perish in five years. At age 40, lifetime risk of developing heart failure is one in five. Diastolic dysfunction heart failure prevalence has increased to 50% of all heart failure. In this context, My research is dedicated to elucidating underlying mechanisms and translating discoveries to new treatments.
education and training
- University of Wisconsin Hospital and Clinics - (Madison, Wisconsin, United States), Postdoctoral Training 2010
- Duke Medical Center - (Durham, North Carolina, United States), Medical Residency 2005
- M.D. in Medical Physiology, Texas A&M Health Science Center - (College Station, Texas, United States) 2002
- M.S. in Electrical Engineering, Air Force Institute of Technology - (Dayton, Ohio, United States) 1986
- B.S. in Electrical Engineering, Texas A&M University - (College Station, Texas, United States) 1985
selected publications
Academic Articles63
- Nelson, S., Beck-Previs, S., Sadayappan, S., Tong, C., & Warshaw, D. M. (2023). Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle.. J Gen Physiol. 155(4), e202213276.
- Nelson, S. R., Previs, S. B., Sadayappan, S., Tong, C., & Warshaw, D. M. (2023). Myosin-binding protein C (MyBP-C) stabilizes, but is not the sole determinant of, SRX myosin in cardiac muscle. Biophysical Journal. 122(3), 169a-170a.
- Koyilot, M. C., Natarajan, P., Hunt, C. R., Sivarajkumar, S., Roy, R., Joglekar, S., ... Yadav, K. K. (2022). Breakthroughs and Applications of Organ-on-a-Chip Technology.. Cells. 11(11), 1828-1828.
- Yang, W., Yan, H., Zhou, F., Pan, Q., Allred, K., Allred, C., ... Guo, S. (2022). Sexual Dimorphism in Control of Heart Failure in Insulin Resistance. The FASEB Journal. 36(S1),
- Tong, C., Rosas, P. C., Leatherman, A. K., & McAlister, L. A. (2022). CARDIAC MYOSIN BINDING PROTEIN-C MEDIATES CALCIUM TO FORCE COUPLING FOR EFFECTIVE CONTRACTION AND RELAXATION. Journal of the American College of Cardiology. 79(9), 317-317.
Chapters3
- Liu, Y., Dostal, D. E., & Tong, C. W. (2021). Isolation of Adult Mouse Cardiomyocytes Using Langendorff Perfusion Apparatus.. Cardiovascular Development. 143-152. Springer Nature.
- Creed, H. A., & Tong, C. W. (2021). Preparation and Identification of Cardiac Myofibrils from Whole Heart Samples.. Cardiovascular Development. 15-24. Springer Nature.
- Jokerst, S., Nizmutdinov, D., Edgar, C., Kaspick, A. M., Tong, C. W., & Dostal, D. E. (2021). Preparation of Neonatal Rat Papillary Muscles for Contractile Studies.. Cardiovascular Development. 31-44. Springer Nature.
Conference Papers41
- Kuempe, J. D., Xi, Y. u., DeSpain, P., Zhang, T., Ojukwu, O., Osborn, A. M., ... Tong, C. W. (2022). Methyltransferase-14 Regulation of Adenosine Methylation on mRNA Contributes to Normal and Adaptive Heart Structure and Function. CIRCULATION RESEARCH. 131(12), E177-E178.
- Rosas, P. C., Warren, C. M., Batra, A., Creed, H., Solaro, R. J., & Tong, C. W. (2019). Cardiac Myosin Binding Protein-C Phosphorylation in Ser-273 and Ser-282 is Critical to Maintain Cardiac Function During Aging. CIRCULATION RESEARCH. 125,
- Tong, C. W., Creed, H. A., Tsai, S., Kuo, L., & Hein, T. W. (2019). Coronary Arteriolar Vasomotor Dysfunction Precedes Cardiac Diastolic Dysfunction in Diabetic Cardiomyopathy. CIRCULATION. 140,
- Tong, C. W., Wang, L., Jin, Y., Liu, Y., Creed, H., Wang, J., Muthuchamy, M., & Peng, X. u. (2019). Pressure Stress Triggers Src/Focal Adhesion Kinase Complex to Phosphorylate Tyrosine Residue of Cardiac Myosin Binding Protein-C. CIRCULATION. 140,
- Tong, C., Rosas, P., Kidwell, D., & Liu, Y. (2017). CARDIAC MYOSIN BINDING PROTEIN-C DE-PHOSPHORYLATION MEDIATED SLOWING OF CROSS-DETACHMENT WORSENS HEART FAILURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 69(11), 670-670.
Repository Documents / Preprints4
- Nelson, S., Previs, S. B., Sadayappan, S., Tong, C., & Warshaw, D. M. (2022). Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle.
- Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Ragan, K. B., Tong, C. W., ... West, A. P. (2022). ZBP1 sequesters cGAS in the cytoplasm and sustains type I interferon responses to mitochondrial DNA.
- Lei, Y., Martinez, C. G., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., ... West, A. P. (2020). Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
- Wang, L., Jin, Y., Wang, J., Liu, Y., Wang, R., Zhang, S. L., ... Peng, X. u. (2020). Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo.
in the news
- Presidential Clinical Research Partnership Grants Fund Six Research Projects Texas A&M Today July 23, 2020
researcher on
Principal Investigator3
recent teaching activities
- BICH491 Hnr-research Instructor
- BICH491 Research Instructor
- GENE491 Hnr-research Instructor
- GENE491 Research Instructor
- GENE491 Research: In-ab Instructor
Email
ctong@tamu.edu
First Name
Carl
Last Name
Tong
mailing address
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS
Temple, TX 76504
USA