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Tong, Carl individual record
Associate Professor
Positions:
UN Sustainable Development Goals:
UN Sustainable Development Goals:
overview

Cardiovascular disease remains as the number one cause of mortality. About 50% of heart failure patients will perish in five years. At age 40, lifetime risk of developing heart failure is one in five. Diastolic dysfunction heart failure prevalence has increased to 50% of all heart failure. In this context, My research is dedicated to elucidating underlying mechanisms and translating discoveries to new treatments.

education and training
selected publications
Academic Articles63
  • Nelson, S., Beck-Previs, S., Sadayappan, S., Tong, C., & Warshaw, D. M. (2023). Myosin-binding protein C stabilizes, but is not the sole determinant of SRX myosin in cardiac muscle.. J Gen Physiol. 155(4), e202213276.
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  • Nelson, S. R., Previs, S. B., Sadayappan, S., Tong, C., & Warshaw, D. M. (2023). Myosin-binding protein C (MyBP-C) stabilizes, but is not the sole determinant of, SRX myosin in cardiac muscle. Biophysical Journal. 122(3), 169a-170a.
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  • Koyilot, M. C., Natarajan, P., Hunt, C. R., Sivarajkumar, S., Roy, R., Joglekar, S., ... Yadav, K. K. (2022). Breakthroughs and Applications of Organ-on-a-Chip Technology.. Cells. 11(11), 1828-1828.
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  • Yang, W., Yan, H., Zhou, F., Pan, Q., Allred, K., Allred, C., ... Guo, S. (2022). Sexual Dimorphism in Control of Heart Failure in Insulin Resistance. The FASEB Journal. 36(S1),
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  • Tong, C., Rosas, P. C., Leatherman, A. K., & McAlister, L. A. (2022). CARDIAC MYOSIN BINDING PROTEIN-C MEDIATES CALCIUM TO FORCE COUPLING FOR EFFECTIVE CONTRACTION AND RELAXATION. Journal of the American College of Cardiology. 79(9), 317-317.
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5102550100
Chapters3
  • Liu, Y., Dostal, D. E., & Tong, C. W. (2021). Isolation of Adult Mouse Cardiomyocytes Using Langendorff Perfusion Apparatus.. Cardiovascular Development. 143-152. Springer Nature.
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  • Creed, H. A., & Tong, C. W. (2021). Preparation and Identification of Cardiac Myofibrils from Whole Heart Samples.. Cardiovascular Development. 15-24. Springer Nature.
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  • Jokerst, S., Nizmutdinov, D., Edgar, C., Kaspick, A. M., Tong, C. W., & Dostal, D. E. (2021). Preparation of Neonatal Rat Papillary Muscles for Contractile Studies.. Cardiovascular Development. 31-44. Springer Nature.
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Conference Papers41
  • Kuempe, J. D., Xi, Y. u., DeSpain, P., Zhang, T., Ojukwu, O., Osborn, A. M., ... Tong, C. W. (2022). Methyltransferase-14 Regulation of Adenosine Methylation on mRNA Contributes to Normal and Adaptive Heart Structure and Function. CIRCULATION RESEARCH. 131(12), E177-E178.
  • Rosas, P. C., Warren, C. M., Batra, A., Creed, H., Solaro, R. J., & Tong, C. W. (2019). Cardiac Myosin Binding Protein-C Phosphorylation in Ser-273 and Ser-282 is Critical to Maintain Cardiac Function During Aging. CIRCULATION RESEARCH. 125,
  • Tong, C. W., Creed, H. A., Tsai, S., Kuo, L., & Hein, T. W. (2019). Coronary Arteriolar Vasomotor Dysfunction Precedes Cardiac Diastolic Dysfunction in Diabetic Cardiomyopathy. CIRCULATION. 140,
  • Tong, C. W., Wang, L., Jin, Y., Liu, Y., Creed, H., Wang, J., Muthuchamy, M., & Peng, X. u. (2019). Pressure Stress Triggers Src/Focal Adhesion Kinase Complex to Phosphorylate Tyrosine Residue of Cardiac Myosin Binding Protein-C. CIRCULATION. 140,
  • Tong, C., Rosas, P., Kidwell, D., & Liu, Y. (2017). CARDIAC MYOSIN BINDING PROTEIN-C DE-PHOSPHORYLATION MEDIATED SLOWING OF CROSS-DETACHMENT WORSENS HEART FAILURE. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 69(11), 670-670.
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5102550100
Repository Documents / Preprints4
  • Nelson, S., Previs, S. B., Sadayappan, S., Tong, C., & Warshaw, D. M. (2022). Myosin-Binding Protein C Stabilizes, But Is Not the Sole Determinant of SRX Myosin in Cardiac Muscle.
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  • Lei, Y., VanPortfliet, J. J., Chen, Y., Bryant, J. D., Ragan, K. B., Tong, C. W., ... West, A. P. (2022). ZBP1 sequesters cGAS in the cytoplasm and sustains type I interferon responses to mitochondrial DNA.
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  • Lei, Y., Martinez, C. G., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., ... West, A. P. (2020). Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
  • Wang, L., Jin, Y., Wang, J., Liu, Y., Wang, R., Zhang, S. L., ... Peng, X. u. (2020). Src/FAK complex phosphorylates cardiac myosin binding protein c (cMyBP-C) in vitro and in vivo.
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in the news
researcher on
Principal Investigator3
recent teaching activities
5102550100
Email
ctong@tamu.edu
First Name
Carl
Last Name
Tong
mailing address
Texas A&M Health Science Center; Medical Physiology; 1114 TAMUS
Temple, TX 76504
USA
UN Sustainable Development Goals:
UN Sustainable Development Goals: