overview

My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.



The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

selected publications
Academic Articles215
  • Erber, L., Goodman, S., Wright, F. A., Chiu, W. A., Tretyakova, N. Y., & Rusyn, I. (2021). Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene. 34(11), 2375-2383.
    doi badge
  • Burnett, S. D., Karmakar, M., Murphy, W. J., Chiu, W. A., & Rusyn, I. (2021). A new approach method for characterizing inter-species toxicodynamic variability.. 84(24), 1020-1039.
    doi badge
  • doi badge
  • Aly, N. A., Casillas, G., Luo, Y., McDonald, T. J., Wade, T. L., Zhu, R., ... Rusyn, I (2021). Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks.. J Expo Sci Environ Epidemiol. 31(5), 810-822.
    doi badge pubmed badge
  • doi badge pubmed badge
Books2
  • Pogribny, I. P., & Rusyn, I. (2013). Environmental Toxicants, Epigenetics, and Cancer.
    doi badge pubmed badge
  • Allen, N., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., ... Russell, D. (2010). Alcohol consumption and ethyl carbamate.
Chapters2
  • (2018). Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.. 20TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING. 28th European Symposium on Computer Aided Process Engineering. 421-426. Elsevier.
    doi badge pubmed badge
  • Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary Methyl Deficiency, microRNA Expression and Susceptibility to Liver Carcinogenesis. RETURN OF OMEGA-3 FATTY ACIDS INTO THE FOOD SUPPLY. Personalized Nutrition. 123-130. KARGER.
    doi badge pubmed badge
Conference Papers46
  • doi badge
  • Furuya, S., Kosyk, O., Uehara, T., Odena, G., Kato, Y., Kono, H., Bataller, R., & Rusyn, I. (2014). P307 ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE. 60(1), s168-S168.
    doi badge
researcher on
chaired theses and dissertations
Email
irusyn@tamu.edu
First Name
Ivan
Last Name
Rusyn
mailing address
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU
College Station, TX 77843-4458
USA