My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.

The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

selected publications
Academic Articles215
  • Erber, L., Goodman, S., Wright, F. A., Chiu, W. A., Tretyakova, N. Y., & Rusyn, I. (2021). Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene. 34(11), 2375-2383.
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  • Burnett, S. D., Karmakar, M., Murphy, W. J., Chiu, W. A., & Rusyn, I. (2021). A new approach method for characterizing inter-species toxicodynamic variability.. 84(24), 1020-1039.
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  • Aly, N. A., Casillas, G., Luo, Y., McDonald, T. J., Wade, T. L., Zhu, R., ... Rusyn, I (2021). Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks.. J Expo Sci Environ Epidemiol. 31(5), 810-822.
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  • Pogribny, I. P., & Rusyn, I. (2013). Environmental Toxicants, Epigenetics, and Cancer.
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  • Allen, N., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., ... Russell, D. (2010). Alcohol consumption and ethyl carbamate.
  • (2018). Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.. 20TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING. 28th European Symposium on Computer Aided Process Engineering. 421-426. Elsevier.
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  • Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary Methyl Deficiency, microRNA Expression and Susceptibility to Liver Carcinogenesis. RETURN OF OMEGA-3 FATTY ACIDS INTO THE FOOD SUPPLY. Personalized Nutrition. 123-130. KARGER.
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Conference Papers46
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  • Furuya, S., Kosyk, O., Uehara, T., Odena, G., Kato, Y., Kono, H., Bataller, R., & Rusyn, I. (2014). P307 ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE. 60(1), s168-S168.
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researcher on
chaired theses and dissertations
First Name
Last Name
mailing address
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU
College Station, TX 77843-4458