Scholars

My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.

The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

education and training

Ph.D. in Toxicology, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 2000
M.D. in Medicine, Bogomolets National Medical University - (Kiev, Ukraine) 1994

selected publications

Academic Articles225

Sakolish, C., Chen, Z., Dalaijamts, C., Mitra, K., Liu, Y., Fulton, T., ... Chiu, W. A. (2020). Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling. TOXICOLOGY IN VITRO. 63, 104752-104752.
Danforth, C., Chiu, W. A., Rusyn, I., Schultz, K., Bolden, A., Kwiatkowski, C., & Craft, E. (2020). An integrative method for identification and prioritization of constituents of concern in produced water from onshore oil and gas extraction. Environment International. 134, 105280-105280.
Keele, G. R., Quach, B. C., Israel, J. W., Chappell, G. A., Lewis, L., Safi, A., ... Furey, T. S. (2020). Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation.. PLoS Genet. 16(1), e1008537-e1008537.
Dalaijamts, C., Cichocki, J. A., Luo, Y., Rusyn, I., & Chiu, W. A. (2020). PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicology and Applied Pharmacology. 400, 115069-115069.
Lewis, L., Borowa-Mazgaj, B., de Conti, A., Chappell, G. A., Luo, Y., Bodnar, W., ... Rusyn, I. (2019). Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse.. Chemical Research in Toxicology. 32(5), 887-898.

Books2

Pogribny, I. P., & Rusyn, I. (2013). Environmental toxicants, epigenetics, and cancer.
Allen, N., Anderson, L. M., Beland, F. A., BÃ©nichou, J., Beral, V., Bloomfield, K., ... Russell, D. (2010). Alcohol consumption and ethyl carbamate.

Chapters2

Onel, M., Beykal, B., Wang, M., Grimm, F. A., Zhou, L., Wright, F. A., ... Pistikopoulos, E. N. (2018). Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques. 20TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING. 28th European Symposium on Computer Aided Process Engineering. (pp. 421-426). Elsevier.
Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis. Personalized Nutrition: Translating Nutrigenetic/Nutrigenomic Research into Dietary Guidelines. (pp. 123-130).