overview

My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.



The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

selected publications
Academic Articles217
  • Erber, L., Goodman, S., Wright, F. A., Chiu, W. A., Tretyakova, N. Y., & Rusyn, I. (2021). Intra- and Inter-Species Variability in Urinary N7-(1-Hydroxy-3-buten-2-yl)guanine Adducts Following Inhalation Exposure to 1,3-Butadiene. Chemical Research in Toxicology. 34(11), 2375-2383.
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  • Burnett, S. D., Blanchette, A. D., Chiu, W. A., & Rusyn, I. (2021). Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors. Chemical Research in Toxicology. 34(9), 2110-2124.
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  • Burns, S. J. (2021). Linear dielectric thermodynamics: A new universal law for optical, dielectric constants. Journal of the American Ceramic Society. 104(5), 2087-2101.
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  • Roman-Hubers, A. T., McDonald, T. J., Baker, E. S., Chiu, W. A., & Rusyn, I. (2021). A Comparative Analysis of Analytical Techniques for Rapid Oil Spill Identification.. Environ Toxicol Chem. 40(4), 1034-1049.
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  • Aly, N. A., Casillas, G., Luo, Y., McDonald, T. J., Wade, T. L., Zhu, R., ... Rusyn, I. (2021). Environmental impacts of Hurricane Florence flooding in eastern North Carolina: temporal analysis of contaminant distribution and potential human health risks.. J Expo Sci Environ Epidemiol. 31(5), 810-822.
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Books2
  • Pogribny, I. P., & Rusyn, I. (2013). Environmental toxicants, epigenetics, and cancer.. Springer Nature.
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  • Allen, N., Anderson, L. M., Beland, F. A., Bnichou, J., Beral, V., Bloomfield, K., ... Russell, D. (2010). Alcohol consumption and ethyl carbamate.
Chapters2
  • Onel, M., Beykal, B., Wang, M., Grimm, F. A., Zhou, L., Wright, F. A., ... Pistikopoulos, E. N. (2018). Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.. 20TH EUROPEAN SYMPOSIUM ON COMPUTER AIDED PROCESS ENGINEERING. Computer Aided Chemical Engineering. 421-426. Elsevier.
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  • Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.. RETURN OF OMEGA-3 FATTY ACIDS INTO THE FOOD SUPPLY. World Review of Nutrition and Dietetics. 123-130. KARGER.
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Conference Papers46
  • Ketelslegers, H., Rusyn, I., & Kamelia, L. (2017). Using new methodologies for a better understanding of the health impacts of petroleum substances. CONCAWE Review. 2017, 15.
  • Rusyn, I. (2015). SYSTEMS BIOLOGY ANALYSIS OF GENETIC AND ENVIRONMENTAL DETERMINANTS OF TOXICITY. DRUG METABOLISM REVIEWS. 47, 19-19.
  • Rusyn, I. (2015). miRNA as population variability-independent biomarkers of toxicity. Toxicology Letters. 238(2), S25-S25.
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  • Blackwleder, A. J., Ma, Z., Li, X., Rusyn, I., & Yang, X. (2014). ADULT EXPOSURE TO ALCOHOL PROMOTES MAMMARY TUMOR DEVELOPMENT IN MMTV-ERBB-2 TRANSGENIC MICE THROUGH ACTIVATION OF ER, AKT AND ERK1/2 SIGNALING. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 38, 109A-109A.
  • Furuya, S., Kosyk, O., Uehara, T., Odena, G., Kato, Y., Kono, H., Bataller, R., & Rusyn, I. (2014). P307 ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE. Journal of Hepatology. 60(1), S168-S168.
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researcher on
chaired theses and dissertations
Email
irusyn@tamu.edu
First Name
Ivan
Last Name
Rusyn
mailing address
Texas A&M University; Veterinary Integrative Biosciences; 4458 TAMU
College Station, TX 77843-4458
USA