- Professor, Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University
My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.
The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.
- Ph.D. in Toxicology, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 2000
- M.D. in Medicine, Bogomolets National Medical University - (Kiev, Ukraine) 1994
Academic Articles266
- Roman-Hubers, A. T., Cordova, A. C., Barrow, M. P., & Rusyn, I. (2023). Analytical chemistry solutions to hazard evaluation of petroleum refining products.. Regul Toxicol Pharmacol. 137, 105310-105310.
- Kato, Y., Lim, A. Y., Sakolish, C., Valdiviezo, A., Moyer, H. L., Hewitt, P., ... Rusyn, I. (2022). Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.. Toxicol In Vitro. 85, 105464-105464.
- Goodman, S., Chappell, G., Guyton, K. Z., Pogribny, I. P., & Rusyn, I. (2022). Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review.. Mutat Res Rev Mutat Res. 789, 108408-108408.
- Roman-Hubers, A. T., Aeppli, C., Dodds, J. N., Baker, E. S., McFarlin, K. M., Letinski, D. J., ... Rusyn, I. (2022). Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight.. Mar Pollut Bull. 185(Pt B), 114360-114360.
- Boysen, G., Rusyn, I., Chiu, W. A., & Wright, F. A. (2022). Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice.. Regul Toxicol Pharmacol. 132, 105171-105171.
Books2
- Pogribny, I. P., & Rusyn, I. (2013). Environmental toxicants, epigenetics, and cancer.. Springer Nature.
- IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2010). Alcohol consumption and ethyl carbamate..
Chapters2
- Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.. PERSONALIZED NUTRITION: TRANSLATING NUTRIGENETIC/NUTRIGENOMIC RESEARCH INTO DIETARY GUIDELINES. 123-130. Karger Publishers.
- Onel, M., Beykal, B., Wang, M., Grimm, F. A., Zhou, L., Wright, F. A., ... Pistikopoulos, E. N. Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.. 28th European Symposium on Computer Aided Process Engineering. 421-426. Elsevier.
Conference Papers46
- Ketelslegers, H., Rusyn, I., & Kamelia, L. (2017). Using new methodologies for a better understanding of the health impacts of petroleum substances. CONCAWE Review. 2017, 15.
- Rusyn, I. (2015). miRNA as population variability-independent biomarkers of toxicity. TOXICOLOGY LETTERS. 238(2), S25-S25.
- Rusyn, I. (2015). SYSTEMS BIOLOGY ANALYSIS OF GENETIC AND ENVIRONMENTAL DETERMINANTS OF TOXICITY. DRUG METABOLISM REVIEWS. 47, 19-19.
- Furuya, S., Kosyk, O., Uehara, T., Odena, G., Kato, Y., Kono, H., Bataller, R., & Rusyn, I. (2014). ACUTE-ON-CHRONIC MODEL OF ALCOHOLIC HEPATITIS IN THE MOUSE. JOURNAL OF HEPATOLOGY. 60(1), S168-S168.
- Odena, G., Morales-Ibanez, O., Affo, S., Furuya, S., Rusyn, I., Altamirano, J., ... Bataller, R. (2014). TRANSLATIONAL STUDY IDENTIFIES NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AS A POTENTIAL MEDIATOR OF LIVER INJURY AND FIBROGENESIS IN ALCOHOLIC HEPATITIS. JOURNAL OF HEPATOLOGY. 60(1), S181-S182.
- Tay Gavin Erickson Lecture Series: 'When Disaster Strikes: Response, Research, and Recovery' University of Massachusetts Amherst November 23, 2020
- New Pandemic Vulnerability Index dashboard maps global spread of COVID-19 The Battalion April 26, 2020
Principal Investigator9
- TEX-VAL: Texas A&M Tissue Chip Validation Center awarded by National Institutes of Health 2016 - 2019
Co-Principal Investigator3
- Center for Translational Environmental Health Research awarded by National Institutes of Health 2014 - 2018
Investigator1
- VIBS285 Directed Studies Instructor
- VIBS645 Prac Eval Human Hlth Rsks Chem Instructor
- VIBS670 Advanced Toxicology Instructor
- VIBS691 Research Instructor
- VTPP673 Metabolic & Detox Mech Instructor
- Lewis, Lauren Anne (2019-12). Inter-Individual Variability in DNA Damage and Epigenetic Effects in Response to 1,3-Butadiene. (Doctoral Dissertation)
- Luo, Yu-Syuan (2018-08). Inter-individual Variability in Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene. (Doctoral Dissertation)
- Seniutkin, Oleksii (2017-05). Effects of Pirfenidone in a Mouse Liver Fibrosis Model. (Master's Thesis)
- Wilson, Melinda R (2016-08). Data Integration and Visualization for Transparent Communication in Read-Across: a Glycol Ether Case Study. (Master's Thesis)