Scholars

Rusyn, Ivan

Professor

Positions:

Professor, Veterinary Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University

Research Areas:

Risk assessment, Toxicology

UN Sustainable Development Goals:

Single Page Bio

Profile Summary

irusyn@tamu.edu

1 979 458 9866

Co-author Network

Map of Science

Co-investigator Network

ORCID

0000-0001-9340-7384

UN Sustainable Development Goals:

Research Areas:

Risk assessment, Toxicology

overview

My laboratory has an active research portfolio funded by the National Institutes of Health and the US EPA with a focus on the mechanisms of action of environmental toxicants and the genetic determinants of the susceptibility to toxicant-induced injury. Through a combination of in vivo animal studies and experiments that utilize cellular and molecular models, we aim to better understand why certain chemicals cause cancer or organ damage in rodents and whether humans in general, or any susceptible sub-population in particular, are at risk from similar exposures.

The main focus of our inter-disciplinary research is on improving the linkages between exposures and adverse health effects Specifically, we develop innovative experimental methods and computational tools which enable analysis of data across multiple dimensions including SNPs, -omic endpoints, multiple chemicals and traditional toxicity phenotypes.

education and training

Ph.D. in Toxicology, University of North Carolina at Chapel Hill - (Chapel Hill, North Carolina, United States) 2000
M.D. in Medicine, Bogomolets National Medical University - (Kiev, Ukraine) 1994

selected publications

Academic Articles266

Roman-Hubers, A. T., Cordova, A. C., Barrow, M. P., & Rusyn, I. (2023). Analytical chemistry solutions to hazard evaluation of petroleum refining products.. Regul Toxicol Pharmacol. 137, 105310-105310.
Kato, Y., Lim, A. Y., Sakolish, C., Valdiviezo, A., Moyer, H. L., Hewitt, P., ... Rusyn, I. (2022). Analysis of reproducibility and robustness of OrganoPlate 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.. Toxicol In Vitro. 85, 105464-105464.
Goodman, S., Chappell, G., Guyton, K. Z., Pogribny, I. P., & Rusyn, I. (2022). Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: An update of a systematic literature review.. Mutat Res Rev Mutat Res. 789, 108408-108408.
Roman-Hubers, A. T., Aeppli, C., Dodds, J. N., Baker, E. S., McFarlin, K. M., Letinski, D. J., ... Rusyn, I. (2022). Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight.. Mar Pollut Bull. 185(Pt B), 114360-114360.
Boysen, G., Rusyn, I., Chiu, W. A., & Wright, F. A. (2022). Characterization of population variability of 1,3-butadiene derived protein adducts in humans and mice.. Regul Toxicol Pharmacol. 132, 105171-105171.

Books2

Pogribny, I. P., & Rusyn, I. (2013). Environmental toxicants, epigenetics, and cancer.. Springer Nature.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. (2010). Alcohol consumption and ethyl carbamate..

Chapters2

Starlard-Davenport, A., Tryndyak, V., Kosyk, O., Ross, S. R., Rusyn, I., Beland, F. A., & Pogribny, I. P. (2010). Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis.. PERSONALIZED NUTRITION: TRANSLATING NUTRIGENETIC/NUTRIGENOMIC RESEARCH INTO DIETARY GUIDELINES. 123-130. Karger Publishers.
Onel, M., Beykal, B., Wang, M., Grimm, F. A., Zhou, L., Wright, F. A., ... Pistikopoulos, E. N. Optimal Chemical Grouping and Sorbent Material Design by Data Analysis, Modeling and Dimensionality Reduction Techniques.. 28th European Symposium on Computer Aided Process Engineering. 421-426. Elsevier.