Research in our lab centers on the molecular and cellular mechanisms underlying the formation, maintenance and pathology of synapses, the connections between nerve cells and their targets. Because of its simplicity and experimental accessibility we have used the vertebrate neuromuscular junction (NMJ) as our model system. The NMJ is the synapse between a motor neuron and a skeletal muscle fiber. We address these problems using state-of-the-art mouse molecular genetic techniques in combination with standard molecular, cellular, and immunological approaches.
- New York University - (New York, New York, United States), Postdoctoral Training 2000
- New Mexico State University - (Las Cruces, New Mexico, United States), Postdoctoral Training 1998
- Stanford University - (Stanford, California, United States), Postdoctoral Training 1997
- Ph.D. in Molecular and Cell Biology, University of Maryland, Baltimore - (Baltimore, Maryland, United States) 1993
- B.S. in Biology, University of the Andes - (Mérida, Venezuela) 1986
- Rimer, M. (2020). Extracellular signal-regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle. Neurosci Lett. 715, 134671-134671.
- Lee, Y. I., & Rimer, M. (2020). Wesley J. Thompson (1947–2019). FRONTIERS IN MOLECULAR NEUROSCIENCE. 13, 91.
- Rimer, M., Seaberg, B. L., Yen, P., Lam, S., Hastings, R. L., Lee, Y. I., ... Ko, C. (2019). Nerve sprouting capacity in a pharmacologically induced mouse model of spinal muscular atrophy. SCIENTIFIC REPORTS. 9(1), 7799.
- Wang, S., Seaberg, B., Paez-Colasante, X., & Rimer, M. (2017). Erratum: Corrigendum: Defective Acetylcholine Receptor Subunit Switch Precedes Atrophy of Slow-Twitch Skeletal Muscle Fibers Lacking ERK1/2 Kinases in Soleus Muscle. SCIENTIFIC REPORTS. 7(1), 45420.
- Seaberg, B., Henslee, G., Wang, S., Paez-Colasante, X., Landreth, G. E., & Rimer, M. (2015). Muscle-Derived Extracellular Signal-Regulated Kinases 1 and 2 Are Required for the Maintenance of Adult Myofibers and Their Neuromuscular Junctions. Mol Cell Biol. 35(7), 1238-1253.