Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma | Academic Article individual record
abstract

The incidence of hepatocellular carcinoma (HCC) is significantly elevated in a Hispanic community in Bexar County, Texas. Chronic exposure to dietary aflatoxins (AFs) is a major risk factor for HCC; increased risk has been linked to polycyclic aromatic hydrocarbon (PAH) co-exposure and hepatitis virus infection. The aims of this study were to assess AF and PAH exposures, investigate dietary factors that may contribute to increased AF exposure, and determine the prevalence of hepatitis virus infection in Bexar Co. Blood and urine samples were collected from 184 volunteers for biomarker analyses and hepatitis screening. Serum AFB(1)-lysine adduct, urinary AFM(1) and 1-hydroxypyrene (1-OHP) levels were measured using high-performance liquid chromatography. The average AFB(1)-lysine adduct level detected in 20.6% of serums was 3.84 ± 3.11 pg/mg albumin (range 1.01-16.57 pg/mg). AFM(1) was detected in 11.7% of urines, averaging 223.85 ± 250.56 pg/mg creatinine (range 1.89-935.49 pg/mg). AFM(1) detection was associated with increased consumption of corn tortillas (p=0.009), nuts (p=0.033) and rice (p=0.037). A significant difference was observed between mean 1-OHP values of non-smokers (0.07 ± 0.13) and smokers (0.80 ± 0.68) μmol/mol creatinine (p<0.01). A high hepatitis C virus positivity rate (7.1%) was observed. Findings suggest that the incidence and level of AF and PAH exposure were less than those observed in a high-risk population; however, participants consuming higher amounts of foods prone to AF contamination may be more vulnerable to exposure and interactions with other environmental/biological factors (i.e., HCV).

author list (cited authors)
Johnson, N. M., Qian, G., Xu, L. i., Tietze, D., Marroquin-Cardona, A., Robinson, A., ... Phillips, T. D.
publication date
2010
publisher
Elsevier bv Publisher
keywords
  • AflatoxinPolycyclic Aromatic HydrocarbonsHepatocellular CarcinomaHepatitis C VirusBiomarkers Of ExposureFood SafetyBiomonitoring
PubMed Central ID
20870273
identifier
95065SE
Digital Object Identifier (DOI)
start page
6027
end page
6031
volume
408
issue
23