(502) Http failure response for https://api.library.tamu.edu/scholars-discovery/discoveryViews: 502 Bad Gateway
overview

My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction. By manipulating the individual components of a compound it is possible to create a chemical that binds to the protein better than the natural substrate, and prevent the natural reaction from occurring. This is the basis for rational drug design. Our efforts have lead us to collaborations with other labs and scientists in many disciplines as our approach to directed compound design has applications not only in basic research but also in pesticide development, health research and clinical research.

selected publications
Academic Articles240
Chapters1
Conference Papers48
patents
Patents3
chaired theses and dissertations
Email
sacchett@tamu.edu
First Name
James
Last Name
Sacchettini
mailing address
Texas A&M University; Biochemistry & Biophysics; 2128 TAMU
College Station, TX 77843-2128
USA