Rational identification of diet-derived postbiotics for improving intestinal microbiota function. | Academic Article individual record
abstract

The intestinal microbiota plays an important role in a wide range of functions and whole body homeostasis. Recent advances have linked microbiota dysbiosis to conditions ranging from Crohn's disease to cancer. The restoration or strengthening of the intestinal microbiota through diet-based approaches such as probiotics and prebiotics has been proposed for combating the onset or progression of these diseases. In this review, we highlight the importance of postbiotics for the manipulation of the intestinal microbiota, with special emphasis on systems biology computational tools and targeted metabolomics for the rational discovery and identification of these bioactive molecules. The identification of novel postbiotics and the pathways responsible for their production should lead to improved mechanistic understanding of the role that specific probiotics, prebiotics, and postbiotics have in restoring intestinal microbiota composition and function.

publication outlet

Curr Opin Biotechnol

author list (cited authors)
Klemashevich, C., Wu, C., Howsmon, D., Alaniz, R. C., Lee, K., & Jayaraman, A.
publication date
2014
publisher
Elsevier bv Publisher
keywords
  • Probiotics
  • Intestines
  • Systems Biology
  • Microbiota
  • Diet
  • Prebiotics
  • Metabolomics
  • Animals
  • Humans
altmetric score

4.25

citation count

43

PubMed ID
24679263
identifier
83424SE
Digital Object Identifier (DOI)
start page
85
end page
90
volume
26