Griffith, William
individual record
Regents Professor and Department Head
Positions:
- Regents Professor and Department Head, Neuroscience and Experimental Therapeutics, College of Medicine
overview
Our long term research goals are to identify the cellular and molecular mechanisms responsible for age-related changes in cellular function that contribute to detrimental aging, and to develop targeted therapies to reverse age-related deficits. We utilize electrophyiological, optogenetic and calcium imaging techniques in animal models of aging and disease. Our research has focused on the basic idea that compensatory changes occur in in brain function during aging and identification of this brain activity will provide an important first step in identifying potential targets for future drug therapies.
education and training
- Baylor College of Medicine - (Houston, Texas, United States), Postdoctoral Training 1983
- University of London - (London, United Kingdom), Postdoctoral Training 1982
- Ph.D. in Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston - (Galveston, Texas, United States) 1980
- M.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1975
- B.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1973
selected publications
Academic Articles68
- Bang, E., Fincher, A. S., Nader, S., Murchison, D. A., & Griffith, W. H. (2022). Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons. The Journal of Neuroscience. 42(6), 1020-1034.
- Bang, E., Tobery, A., Montgomery, K. S., Fincher, A. S., Earnest, D. J., Murchison, D. A., & Griffith, W. H. (2021). Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging.. Front Aging Neurosci. 13, 673155.
- Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.. Brain Res. 1746, 147024-147024.
- Montgomery, K. S., Murchison, D., & Griffith, W. H. (2018). P3‐169: OPTOGENETIC QUANTAL ANALYSIS OF BASAL FOREBRAIN SYNAPTIC TRANSMISSION WITH PHARMACOLOGICAL TESTING OF SYNAPTIC ACTIVITY WITH GLUTAMATE AND CALCIUM MODULATORS. Alzheimer's & Dementia. 14(7S_Part_21), p1132-p1133.
- Montgomery, K. S., DuBois, D. W., Bancroft, E., Provasek, V., & Griffith, W. H. (2017). [P1–127]: TARGETING PRE‐DEMENTIA SYNAPTIC MECHANISMS DURING AGING AND COGNITIVE IMPAIRMENT. Alzheimer's & Dementia. 13(7S_Part_5), p290-p290.
Chapters3
- Griffith, W. H., Han, S., McCool, B. A., & Murchison, D. (2006). Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons. Neuroanatomical Tract-Tracing 3. 142-174. Springer US.
- Shinnick-Gallagher, P., Gallagher, J. P., & Griffith, W. H. (1986). Inhibition in Parasympathetic Ganglia. Autonomic and Enteric Ganglia. 353-367. Springer US.
- Griffith, W. H., Gallagher, J. P., & Gallagher, P. S. (1981). MAMMALIAN PARASYMPATHETIC GANGLIA FIRE SPONTANEOUS ACTION POTENTIALS AND TRANSMIT SLOW SYNAPTIC POTENTIALS. Physiology of Excitable Membranes. 347-350. Elsevier.
Conference Papers4
- Pal, S., Meininger, C. J., Gasheva, O., Griffith, W., Zawieja, D. C., & Gashev, A. A. (2018). Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. JOURNAL OF IMMUNOLOGY. 200(1),
- Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cyclerelated effects of neurosteroids on GABAA receptormediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
- Schilling, M., Durdin, T., Abbott, L. C., & Griffith, W. H. (2011). Ultrastructural analysis of the cellular distribution of mitochondria in cholinergic basal forebrain neurons during aging in the mouse. The FASEB Journal. 25, 677.15-677.15.
- Wang, H., Griffith, W. H., McDermott, A. N., Murchison, D., & Frye, G. D. (2008). Maturation and Pharmacological Properties of Postsynaptic GABAA Receptors. The FASEB Journal. 22(S1), 1127.12-1127.12.
researcher on
Principal Investigator3
- Estrogens, Ovarian Aging and Calcium Channel Modulation awarded by DHHS-NIH-National Institute On Aging 2012 - 2017
Co-Principal Investigator3
Investigator1
- Epigenetics of the Aging Astrocyte: Implications for Stroke awarded by DHHS-NIH-National Institute On Aging 2018 - 2023
awards and honors
recent teaching activities
- MSCI691 Research Credit: Medical Sci Instructor
- NRSC485 Directed Studies Instructor
- NRSC491 Hnr-research Instructor
- NRSC491 Research Instructor
- NRSC691 Research Instructor
chaired theses and dissertations
- Savjani, Ricky R (2018-05). Functional Organization of the Human Brain: How We See, Feel, and Decide.. (Doctoral Dissertation)
Email
whgriff@tamu.edu
First Name
William
Last Name
Griffith
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807-3260
USA