Scholars

Griffith, William

Regents Professor and Department Head

Positions:

Regents Professor and Department Head, Neuroscience and Experimental Therapeutics, College of Medicine

Single Page Bio

whgriff@tamu.edu

1 979 436 0315

Co-author Network

Map of Science

Co-investigator Network

overview

Our long term research goals are to identify the cellular and molecular mechanisms responsible for age-related changes in cellular function that contribute to detrimental aging, and to develop targeted therapies to reverse age-related deficits. We utilize electrophyiological, optogenetic and calcium imaging techniques in animal models of aging and disease. Our research has focused on the basic idea that compensatory changes occur in in brain function during aging and identification of this brain activity will provide an important first step in identifying potential targets for future drug therapies.

education and training

Baylor College of Medicine - (Houston, Texas, United States), Postdoctoral Training 1983
University of London - (London, United Kingdom), Postdoctoral Training 1982
Ph.D. in Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston - (Galveston, Texas, United States) 1980
M.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1975
B.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1973

selected publications

Academic Articles67

Bang, E., Tobery, A., Montgomery, K. S., Fincher, A. S., Earnest, D. J., Murchison, D. A., & Griffith, W. H. (2021). Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging. Frontiers in Aging Neuroscience. 13, 673155.
Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome. Brain Research. 1746, 147024-147024.
Montgomery, K. S., Murchison, D., & Griffith, W. H. (2018). OPTOGENETIC QUANTAL ANALYSIS OF BASAL FOREBRAIN SYNAPTIC TRANSMISSION WITH PHARMACOLOGICAL TESTING OF SYNAPTIC ACTIVITY WITH GLUTAMATE AND CALCIUM MODULATORS. Alzheimer's & Dementia. 14(7), p1132-p1133.
Montgomery, K. S., DuBois, D. W., Bancroft, E., Provasek, V., & Griffith, W. H. (2017). TARGETING PRE-DEMENTIA SYNAPTIC MECHANISMS DURING AGING AND COGNITIVE IMPAIRMENT. Alzheimer's & Dementia. 13(7), p290-P290.
Damborsky, J. C., Griffith, W. H., & Winzer-Serhan, U. H. (2014). Neonatal nicotine exposure increases excitatory synaptic transmission and attenuates nicotine-stimulated GABA release in the adult rat hippocampus. Neuropharmacology. 88, 187-198.

Chapters3

Griffith, W. H., Han, S., McCool, B. A., & Murchison, D. (2006). Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons. Neuroanatomical Tract-Tracing 3. (pp. 142-174). Springer US.
Shinnick-Gallagher, P., Gallagher, J. P., & Griffith, W. H. (1986). Inhibition in Parasympathetic Ganglia. Autonomic and Enteric Ganglia. (pp. 353-367). Springer US.
Griffith, W. H., Gallagher, J. P., & Gallagher, P. S. (1981). MAMMALIAN PARASYMPATHETIC GANGLIA FIRE SPONTANEOUS ACTION POTENTIALS AND TRANSMIT SLOW SYNAPTIC POTENTIALS. Physiology of Excitable Membranes. (pp. 347-350). Elsevier.