Our long term research goals are to identify the cellular and molecular mechanisms responsible for age-related changes in cellular function that contribute to detrimental aging, and to develop targeted therapies to reverse age-related deficits. We utilize electrophyiological, optogenetic and calcium imaging techniques in animal models of aging and disease. Our research has focused on the basic idea that compensatory changes occur in in brain function during aging and identification of this brain activity will provide an important first step in identifying potential targets for future drug therapies.
- Baylor College of Medicine - (Houston, Texas, United States), Postdoctoral Training 1983
- University of London - (London, United Kingdom), Postdoctoral Training 1982
- Ph.D. in Pharmacology and Toxicology, The University of Texas Medical Branch at Galveston - (Galveston, Texas, United States) 1980
- M.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1975
- B.S. in Biology, Lamar University - (Beaumont, Texas, United States) 1973
- Bizon, J. L., LaSarge, C. L., Montgomery, K. S., McDermott, A. N., Setlow, B., & Griffith, W. H. (2009). Spatial reference and working memory across the lifespan of male Fischer 344 rats. Neurobiology of Aging. 30(4), 646-655.
- LaSarge, C. L., Montgomery, K. S., Tucker, C., Slaton, G. S., Griffith, W. H., Setlow, B., & Bizon, J. L. (2007). Deficits across multiple cognitive domains in a subset of aged Fischer 344 rats. Neurobiology of Aging. 28(6), 928-936.
- Murchison, D., & Griffith, W. H. (2007). Calcium buffering systems and calcium signaling in aged rat basal forebrain neurons. Aging cell. 6(3), 297-305.
- Huang, L. Z., Liu, X., Griffith, W. H., & Winzer-Serhan, U. H. (2007). Chronic Neonatal Nicotine Increases Anxiety But Does Not Impair Cognition in Adult Rats. BEHAVIORAL NEUROSCIENCE. 121(6), 1342-1352.
- Etheredge, J. A., Murchison, D., Abbott, L. C., & Griffith, W. H. (2007). Functional compensation by other voltage-gated Ca2+ channels in mouse basal forebrain neurons with CaV2.1 mutations. Brain Research. 1140(1), 105-119.
- Griffith, W. H., Han, S., McCool, B. A., & Murchison, D. (2006). Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons. Neuroanatomical Tract-Tracing 3. (pp. 142-174). Springer Us.
- Pal, S., Meininger, C. J., Gasheva, O., Griffith, W., Zawieja, D. C., & Gashev, A. A. (2018). Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. JOURNAL OF IMMUNOLOGY. 200(1),
- Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cycle-related effects of neurosteroids on GABA-A receptor-mediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26,
- Schilling, M., Durdin, T., Abbott, L. C., & Griffith, W. H. (2011). Ultrastructural analysis of the cellular distribution of mitochondria in cholinergic basal forebrain neurons during aging in the mouse. The FASEB Journal. 25,
- Wang, H., Griffith, W. H., McDermott, A. N., Murchison, D., & Frye, G. D. (2008). Maturation and Pharmacological Properties of Postsynaptic GABAA Receptors. The FASEB Journal. 22,