Griffith, William individual record
Regents Professor and Department Head
Positions:
overview

Our long term research goals are to identify the cellular and molecular mechanisms responsible for age-related changes in cellular function that contribute to detrimental aging, and to develop targeted therapies to reverse age-related deficits. We utilize electrophyiological, optogenetic and calcium imaging techniques in animal models of aging and disease. Our research has focused on the basic idea that compensatory changes occur in in brain function during aging and identification of this brain activity will provide an important first step in identifying potential targets for future drug therapies.

selected publications
Academic Articles68
  • Bang, E., Fincher, A. S., Nader, S., Murchison, D. A., & Griffith, W. H. (2022). Late-Onset, Short-Term Intermittent Fasting Reverses Age-Related Changes in Calcium Buffering and Inhibitory Synaptic Transmission in Mouse Basal Forebrain Neurons. The Journal of Neuroscience. 42(6), 1020-1034.
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  • Bang, E., Tobery, A., Montgomery, K. S., Fincher, A. S., Earnest, D. J., Murchison, D. A., & Griffith, W. H. (2021). Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging.. Front Aging Neurosci. 13, 673155.
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  • Rees, K. A., Halawa, A. A., Consuegra-Garcia, D., Golub, V. M., Clossen, B. L., Tan, A. M., ... Winzer-Serhan, U. H. (2020). Molecular, physiological and behavioral characterization of the heterozygous Df[h15q13]/+ mouse model associated with the human 15q13.3 microdeletion syndrome.. Brain Res. 1746, 147024-147024.
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  • Montgomery, K. S., Murchison, D., & Griffith, W. H. (2018). P3‐169: OPTOGENETIC QUANTAL ANALYSIS OF BASAL FOREBRAIN SYNAPTIC TRANSMISSION WITH PHARMACOLOGICAL TESTING OF SYNAPTIC ACTIVITY WITH GLUTAMATE AND CALCIUM MODULATORS. Alzheimer's & Dementia. 14(7S_Part_21), p1132-p1133.
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  • Montgomery, K. S., DuBois, D. W., Bancroft, E., Provasek, V., & Griffith, W. H. (2017). [P1–127]: TARGETING PRE‐DEMENTIA SYNAPTIC MECHANISMS DURING AGING AND COGNITIVE IMPAIRMENT. Alzheimer's & Dementia. 13(7S_Part_5), p290-p290.
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Chapters3
  • Griffith, W. H., Han, S., McCool, B. A., & Murchison, D. (2006). Molecules and Membrane Activity: Single-Cell RT-PCR and Patch-Clamp Recording from Central Neurons. Neuroanatomical Tract-Tracing 3. 142-174. Springer US.
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  • Shinnick-Gallagher, P., Gallagher, J. P., & Griffith, W. H. (1986). Inhibition in Parasympathetic Ganglia. Autonomic and Enteric Ganglia. 353-367. Springer US.
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  • Griffith, W. H., Gallagher, J. P., & Gallagher, P. S. (1981). MAMMALIAN PARASYMPATHETIC GANGLIA FIRE SPONTANEOUS ACTION POTENTIALS AND TRANSMIT SLOW SYNAPTIC POTENTIALS. Physiology of Excitable Membranes. 347-350. Elsevier.
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Conference Papers4
  • Pal, S., Meininger, C. J., Gasheva, O., Griffith, W., Zawieja, D. C., & Gashev, A. A. (2018). Aging-associated alterations in lymphatic vessels and mast cells in perilymphatic tissues. JOURNAL OF IMMUNOLOGY. 200(1),
  • Carver, C., Wu, X., Murchison, D., Griffith, W., & Reddy, D. S. (2012). Ovarian cyclerelated effects of neurosteroids on GABAA receptormediated phasic and tonic currents in the hippocampus. The FASEB Journal. 26(S1), 1048.3-1048.3.
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  • Schilling, M., Durdin, T., Abbott, L. C., & Griffith, W. H. (2011). Ultrastructural analysis of the cellular distribution of mitochondria in cholinergic basal forebrain neurons during aging in the mouse. The FASEB Journal. 25, 677.15-677.15.
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  • Wang, H., Griffith, W. H., McDermott, A. N., Murchison, D., & Frye, G. D. (2008). Maturation and Pharmacological Properties of Postsynaptic GABAA Receptors. The FASEB Journal. 22(S1), 1127.12-1127.12.
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recent teaching activities
chaired theses and dissertations
Email
whgriff@tamu.edu
First Name
William
Last Name
Griffith
mailing address
Texas A&M Health Science Center; Neuroscience & Experimental Therapeutics; 1359 TAMUS
Bryan, TX 77807-3260
USA