My research interests lie at the intersection of neuroendocrinology, neuroinflammation and aging. For the last 10 years, my work has focused on ischemic stroke, specifically, to understand how the aging brain copes with stroke. In North America, stroke risk increases with age and in this aging demographic, women are more likely to sustain a stroke and more likely to have long term disability, poor quality of life and have more neuropsychiatric problems after stroke such as depression and cognitive impairment. This problem is compounded by the fact that few stroke therapies are available. Most stroke neuroprotectants have not been successfully translated from the bench to bedside. Using preclinical models, we have focused on acute pathological changes at the blood brain barrier and central and peripheral inflammation as well as long-term consequences, such as changes to reward pathways and post-stroke depression and dementia. I am also interested in developing novel stroke therapies for stroke in this population and our studies on epigenetic modifications such as histone methylation and non-coding (mi)RNA due to aging/stroke have provided several candidate molecules. Our recent work focuses on the role of the gut microbiome and gut metabolites on stroke recovery, and its potential for understanding the pathophysiology of stroke.
Related to my research goals, I am actively interested in promoting the inclusion of sex as a biological variable and attention to sex differences in medicine. Through medical and graduate coursework, research seminars and community talks, I am a vocal advocate for recognizing sex and gender differences in disease processes and drug therapies. I founded the Women's Health in Neuroscience program at Texas A&M University College of Medicine to create a community of researchers and foster collaboration on gender medicine and women's health, and to train new scholars in this area.
- El-Hakim, Y., Mani, K. K., Eldouh, A., Pandey, S., Grimaldo, M. T., Dabney, A., Pilla, R., & Sohrabji, F. (2021). Sex differences in stroke outcome correspond to rapid and severe changes in gut permeability in adult Sprague-Dawley rats. Biology of Sex Differences. 12(1), 14.
- Branyan, T. E., & Sohrabji, F. (2020). Sex differences in stroke co-morbidities. Experimental Neurology. 332, 113384-113384.
- Stewart, C. E., & Sohrabji, F. (2020). Gonadal hormones and stroke risk: PCOS as a case study. Frontiers in Neuroendocrinology. 58, 100853-100853.
- Vemuganti, R., & Sohrabji, F. (2019). Age and Sex Differences in Post-Ischemic Outcome and Therapy. Neurochemistry International. 127, 104472-1.
- Sohrabji, F., & Selvamani, A. (2019). Sex differences in miRNA as therapies for ischemic stroke. Neurochemistry International. 127, 56-63.
- Sohrabji, F., & Hurn, P. D. (2017). Risk Factors: Gender and Sex. Primer on Cerebrovascular Diseases: Second Edition. (pp. 167-170). Elsevier.
- Sohrabji, F. (2016). The Impact of Aging on Ischemic Stroke. Advances in Geroscience. (pp. 161-196). Springer International Publishing.
- Sohrabji, F., Jane Welsh, C., & Reddy, D. S. (2015). Sex Differences in Neurological Diseases. Sex Differences in the Central Nervous System. (pp. 297-323). Elsevier.
- Sohrabji, F. (2015). Cerebrovascular Stroke: Sex Differences and the Impact of Estrogens. Sex Differences and the Impact of Estrogens.. Estrogen Effects on Traumatic Brain Injury: Mechanisms of Neuroprotection and Repair. (pp. 125-141). Elsevier.
- Miranda, R. C., & Sohrabji, F. (1996). Chapter 2. Gonadal Steroid Receptors: Possible Roles in the Etiology and Therapy of Cognitive and Neurological Disorders. Annual Reports in Medicinal Chemistry. (pp. 11-20). Elsevier.
- Park, M. J., & Sohrabji, F. (2016). The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats. JOURNAL OF NEUROINFLAMMATION. 13(1), 300-338.
- Epigenetics of the Aging Astrocyte: Implications for Stroke awarded by DHHS-NIH-National Institute On Aging 2018 - 2023
- Epigenetics of the Aging Astrocyte: Implications for Stroke awarded by DHHS-NIH-National Institute On Aging 2012 - 2017
- Estrogens, Ovarian Aging and Calcium Channel Modulation awarded by DHHS-NIH-National Institute On Aging 2012 - 2017