Neuroimmune Interactions in a Model of Multiple Sclerosis | Conference Paper individual record
abstract

Psychological stress has been implicated in both the onset and exacerbation of multiple sclerosis (MS). Our research has focused on the role of stress at the onset of MS, using the mouse model Theiler's murine encephalomyelitis virus-induced demyelination. Theiler's virus is a natural pathogen of mice that causes a persistent infection of the central nervous system (CNS) and inflammatory immune-mediated demyelination that is very similar to MS. Our research has shown that restraint stress sufficiently increases corticosterone secretion to cause immunosuppression. Stressed mice develop decreased innate and adaptive immune responses, including decreased chemokine and cytokine responses, to virus, which leads to increased viral replication within the CNS. Higher levels of virus then cause increased later demyelinating disease. These findings may have important implications in our understanding of the interactions between stress and the development of autoimmune diseases induced by infectious agents.

author list (cited authors)
Welsh, C. J., Steelman, A. J., Mi, W., Young, C. R., Storts, R., Welsh, T. H., & Meagher, M. W.
publication date
2009
publisher
Wiley Publisher
keywords
  • Interferon
  • Demyelination
  • Th2
  • CD4(+) T Cells
  • Th1
  • Multiple Sclerosis
  • Central Nervous System
  • T Cells
  • Theiler's VirusMultiple SclerosisDemyelinationCentral Nervous SystemAutoimmunityVirusesStressRestraint StressGlucocorticoidsCorticosteroneHpa AxisImmune SystemChemokinesCytokinesNk CellsInterferonMacrophagesInnate ImmunityAdaptive ImmunityTh1Th2T CellsCD4(+) T CellsCd8(+) T CellsInflammation
  • Corticosterone
  • Cytokines
  • Innate Immunity
  • Hpa Axis
  • Restraint Stress
  • Autoimmunity
  • Nk Cells
  • Chemokines
  • Macrophages
  • Cd8(+) T Cells
  • Adaptive Immunity
  • Inflammation
  • Stress
  • Theiler's Virus
  • Viruses
  • Glucocorticoids
  • Immune System
citation count

21