Mycobacterium tuberculosis: a model system for structural genomics | Academic Article individual record
abstract

Over the past five years, genomics has had a major impact on Mycobacterium tuberculosis research. With the publication of the sequences of two virulent strains (H37Rv and CDC1551) and three closely related sequences, M. tuberculosis is becoming a model system for proteomics and structural genomics initiatives. Together with the promise of structures of proteins with novel folds, high-resolution structures of drug targets are providing the basis for rational inhibitor design, with the goal of the development of novel anti-tuberculars. In addition, this work is aiding scientists in the quest for an effective vaccine against this persistent pathogen.

author list (cited authors)
Smith, C. V., & Sacchettini, J. C.
publication date
2003
publisher
Elsevier bv Publisher
keywords
  • Humans
  • Drug Design
  • Genomics
  • Structure-Activity Relationship
  • Antitubercular Agents
  • Gene Expression Regulation, Bacterial
  • Mycobacterium Tuberculosis
  • Bacterial Proteins
  • Protein Structure, Tertiary
  • Protein Conformation
  • Protein Folding
  • Drug Delivery Systems
  • Protein Structure, Secondary
  • Animals
citation count

25