Crystal structure of calcium dodecin (Rv0379), from Mycobacterium tuberculosis with a unique calcium-binding site.
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Academic Article
individual record
abstract
In eukaryotes, calcium-binding proteins play a pivotal role in diverse cellular processes, and recent findings suggest similar roles for bacterial proteins at different stages in their life cycle. Here, we report the crystal structure of calcium dodecin, Rv0379, from Mycobacterium tuberculosis with a dodecameric oligomeric assembly and a unique calcium-binding motif. Structure and sequence analysis were used to identify orthologs of Rv0379 with different ligand-binding specificity.
authors
publication outlet
Protein Sci
author list (cited authors)
Arockiasamy, A., Aggarwal, A., Savva, C. G., Holzenburg, A., & Sacchettini, J. C.
publication date
2011
publisher
Wiley
Publisher
keywords
- Microscopy, Electron
- Binding Sites
- Calcium-Binding Proteins
- Protein Structure, Tertiary
- Molecular Sequence Data
- Protein Binding
- Models, Molecular
- Amino Acid Motifs
- Mycobacterium Tuberculosis
- Amino Acid Sequence
- Spectrophotometry, Atomic
- Crystallography, X-Ray
- Sequence Homology, Amino Acid
- Calcium
- Bacterial Proteins
citation count
7
PubMed ID
21370306
identifier
74699SE
Digital Object Identifier (DOI)
start page
827
end page
833
volume
20
issue
5