Crystallographic protein model-building on the web | Academic Article individual record
abstract

UNLABELLED: X-ray crystallography is the most widely used method to determine the 3D structure of protein molecules. One of the most difficult steps in protein crystallography is model-building, which consists of constructing a backbone and then amino acid side chains into an electron density map. Interpretation of electron density maps represents a major bottleneck in protein structure determination pipelines, and thus, automated techniques to interpret maps can greatly improve the throughput. We have developed WebTex, a simple and yet powerful web interface to TEXTAL, a program that automates this process of fitting atoms into electron density maps. TEXTAL can also be downloaded for local installation. AVAILABILITY: Web interface, downloadable binaries and documentation at http://textal.tamu.edu

author list (cited authors)
Gopal, K., McKee, E., Romo, T., Pai, R., Smith, J., Sacchettini, J., & Ioerger, T.
publication date
2007
published in
keywords
  • Proteins
  • Models, Molecular
  • Software
  • Computer Simulation
  • Crystallography
  • Models, Chemical
  • Sequence Analysis, Protein
  • Internet
  • Algorithms
  • Protein Conformation
citation count

3