Cis -acting mutation affecting GJA5 transcription is underlying the Melanotic within-feather pigmentation pattern in chickens | Academic Article individual record
abstract

Significance The molecular mechanisms underlying pigmentation patterns in animals is to a large extent an unresolved mystery in biology. For example, compared with mammals, birds show a stunning diversity in pigmentation patterns. This study advances the knowledge concerning the mechanisms creating periodic pigmentation patterns in individual feathers. We show that a mutation upstream of GJA5 encoding a gap-junction protein is causing the Melanotic phenotype in domestic chickens. Melanotic affects within-feather pigmentation patterns by enhancing the contrast between dark- and light-colored regions in the feather. The result implies that cell–cell communications between melanocytes and other cells in the feather follicle play a critical role for pattern formation.

publication outlet

Proceedings of the National Academy of Sciences

author list (cited authors)
Li, J., Lee, M., Chen, J., Davis, B. W., Dorshorst, B. J., Siegel, P. B., ... Andersson, L.
publication date
2021
keywords
  • Human Genome
  • Biotechnology
  • Genetics
altmetric score

3.25

citation count

0

identifier
572717SE
Digital Object Identifier (DOI)
start page
e2109363118
volume
118
issue
41