Laser spectroscopic technique for direct identification of a single virus I: FASTER CARS. | Academic Article individual record
abstract

From the famous 1918 H1N1 influenza to the present COVID-19 pandemic, the need for improved viral detection techniques is all too apparent. The aim of the present paper is to show that identification of individual virus particles in clinical sample materials quickly and reliably is near at hand. First of all, our team has developed techniques for identification of virions based on a modular atomic force microscopy (AFM). Furthermore, femtosecond adaptive spectroscopic techniques with enhanced resolution via coherent anti-Stokes Raman scattering (FASTER CARS) using tip-enhanced techniques markedly improves the sensitivity [M. O. Scully, et al, Proc. Natl. Acad. Sci. U.S.A. 99, 10994-11001 (2002)].

publication outlet

Proc Natl Acad Sci U S A

author list (cited authors)
Deckert, V., Deckert-Gaudig, T., Cialla-May, D., Popp, J., Zell, R., Deinhard-Emmer, S., ... Scully, M. O.
publication date
2020
keywords
  • Microscopy, Atomic Force
  • Lasers
  • Limit Of Detection
  • Tip-enhanced Raman Scattering (ters)
  • Virus Detection
  • Spectrum Analysis, Raman
  • Coherent Anti-stokes Raman Scattering (cars)
  • Virion
  • Time
  • Sars-cov-2
altmetric score

12.35

citation count

13

PubMed ID
33093197
identifier
502762SE
Digital Object Identifier (DOI)
start page
27820
end page
27824
volume
117
issue
45