Neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. The laboratory utilizes a variety of cell free, tissue culture and in-vivo techniques to design and characterize a series of carbon nanomaterials that possess the ability to act as catalytic antioxidants as well as support key mitochondrial functions. This NIH-supported research is in collaboration with synthetic nano-chemists at Rice University (Tour Lab) and biochemists at University of Texas Health Science Center Houston (Tsai Lab). The group is testing a variety of engineered modifications of these versatile, non-toxic materials to address specific cell injury and death mechanisms including ferroptosis and interruption in electron transport and oxidative phosphorylation.
A major interest of ours is the role of diabetes in worsening outcome from stroke, a condition that affects minority and rural Texans disproportionally. With a range of research from molecular interactions to whole animal and clinical studies, the work in this lab is deeply translational, leveraging the group's clinical training and experience to insure that conclusions have direct relevance to the disease state, with the ultimate goal of facilitating the identification of new therapies for these major contributors to disability and mortality.
- Ni, Y., Gu, W., Liu, Z., Zhu, Y., Rong, J., Kent, T. A., ... Zhang, H. (2018). RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway. Neuroscience. 371, 60-74.
- Mandel, J. J., Yust-Katz, S., Patel, A. J., Cachia, D., Liu, D., Park, M., ... de Groot, J. F. (2018). Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma.. Neuro-Oncology. 20(1), 113-122.
- Derry, P. J., & Kent, T. A. (2017). Correlating quantitative susceptibility mapping with cognitive decline in Alzheimer's disease.. Brain. 140(8), 2069-2072.
- Zhu, Y., Gao, X., Ni, Y., Li, W., Kent, T. A., Qiao, S., ... Zhang, H. (2017). Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury. Neuroscience. 356, 125-141.
- Miles, S. R., Sharp, C., Tharp, A. T., Stanford, M. S., Stanley, M., Thompson, K. E., & Kent, T. A. (2017). Emotion dysregulation as an underlying mechanism of impulsive aggression: Reviewing empirical data to inform treatments for veterans who perpetrate violence. Aggression and Violent Behavior. 34, 147-153.
- Martini, S. R., & Kent, T. A. (2016). Cerebrovascular disease. Neurology Secrets: Sixth Edition. (pp. 222-233). Elsevier.
- Martini, S. R., & Kent, T. A. (2013). Stroke and Transient Ischemic Attack. Cardiology Secrets: Fourth Edition. (pp. 433-443). Elsevier.
- Mandava, P., Krumpelman, C. S., Murthy, S. B., & Kent, T. A. (2012). A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances. Translational Stroke Research. (pp. 833-861). Springer New York.
- Martini, S. R., & Kent, T. A. (2010). Stroke and TIA. Cardiology Secrets. (pp. 355-362). Elsevier.
- Agris, J. M., de Figuelredo, R., Hillman, G. B., & Kent, T. A. (1991). A Novel Method For 3-D Segmentation And Volume Estimation Of Brain Compartments From MRI. PROCEEDINGS OF THE 16TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY - ENGINEERING ADVANCES: NEW OPPORTUNITIES FOR BIOMEDICAL ENGINEERS, PTS 1&2. 13(pt 1), 68-70.
- Kent, T. A., Simard, J. M., & Jazayeri, A. (1989). Pharmacological characterization of serotonin interactions with cerebral and peripheral vascular smooth muscle. 225-228.