Neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. The laboratory utilizes a variety of cell free, tissue culture and in-vivo techniques to design and characterize a series of carbon nanomaterials that possess the ability to act as catalytic antioxidants as well as support key mitochondrial functions. This NIH-supported research is in collaboration with synthetic nano-chemists at Rice University (Tour Lab) and biochemists at University of Texas Health Science Center Houston (Tsai Lab). The group is testing a variety of engineered modifications of these versatile, non-toxic materials to address specific cell injury and death mechanisms including ferroptosis and interruption in electron transport and oxidative phosphorylation.
A major interest of ours is the role of diabetes in worsening outcome from stroke, a condition that affects minority and rural Texans disproportionally. With a range of research from molecular interactions to whole animal and clinical studies, the work in this lab is deeply translational, leveraging the group's clinical training and experience to insure that conclusions have direct relevance to the disease state, with the ultimate goal of facilitating the identification of new therapies for these major contributors to disability and mortality.
- Kent, T. A., Preskorn, S. H., Glotzbach, R. K., & Irwin, G. H. (1986). Amitriptyline normalizes tetrabenazine-induced changes in cerebral microcirculation. Biol Psychiatry. 21(5-6), 483-491.
- Kent, T. A., Gunn, W. H., Goodwin, D. W., Jones, M. P., Marples, B. W., & Penick, E. C. (1986). Individual differences in state-dependent retrieval effects of alcohol intoxication.. J Stud Alcohol Drugs. 47(3), 241-243.
- Kent, T. A., Nagy, G., Oke, A. F., Preskorn, S. H., & Adams, R. N. (1985). Effect of CO2 on a brain extracellular space marker and evidence of its neuronal modulation. Brain Research. 342(1), 141-144.
- Kent, T. A., Campbell, J. L., Pazdernik, T. L., Hunter, R., Gunn, W. H., & Goodwin, D. W. (1985). Blood platelet uptake of serotonin in men alcoholics.. J Stud Alcohol Drugs. 46(4), 357-359.
- Kent, T. A., & Preskorn, S. H. (1985). A modified method for the simultaneous determination of regional single-transit brain extraction of diffusion-limited compounds and cerebral blood flow: Utilization of non-invasive measurement of transit time. Brain Research. 335(2), 251-255.
- Martini, S. R., & Kent, T. A. (2016). Cerebrovascular disease. Neurology Secrets: Sixth Edition. (pp. 222-233). Elsevier.
- Martini, S. R., & Kent, T. A. (2013). Stroke and Transient Ischemic Attack. Cardiology Secrets: Fourth Edition. (pp. 433-443). Elsevier.
- Mandava, P., Krumpelman, C. S., Murthy, S. B., & Kent, T. A. (2012). A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances. Translational Stroke Research. (pp. 833-861). Springer New York.
- Martini, S. R., & Kent, T. A. (2010). Stroke and TIA. Cardiology Secrets. (pp. 355-362). Elsevier.
- Kent, T., Perez-Polo, R., & Fabian, R. (2007). Functional uncoupling of perivascular nitric oxide production following neonatal hypoxia/ischemia. Journal of Cerebral Blood Flow & Metabolism. 27(SUPPL. 1),
- Kent, T. A., & Hillman, G. R. (2004). A fuzzy rule based approach to identify brain structures using MRI, in the presence of individual anatomical differences. 2, 1000-1001.
- Chang, C. W., Hillman, G. R., Ying, H., Kent, T. A., & Yen, J. (1996). Fuzzy rule-based system for labeling the structures in 3D human brain magnetic. 3, 1978-1982.
- Chang, C. W., Hillman, G. R., Ying, H., Kent, T. A., Yen, J., & IEEE, .. (1996). A fuzzy rule-based system for labeling the structures in 3D human brain magnetic resonance images. 1978-1982.
- Chang, C., Hillman, G. R., Ying, H., Kent, T. A., & Yen, J. (1996). Automatic generation of membership functions for brain MR images. 182-187.