Neurologist and clinician scientist with a basic, translational and clinical research program, focused mostly on stroke and other brain injuries. The laboratory utilizes a variety of cell free, tissue culture and in-vivo techniques to design and characterize a series of carbon nanomaterials that possess the ability to act as catalytic antioxidants as well as support key mitochondrial functions. This NIH-supported research is in collaboration with synthetic nano-chemists at Rice University (Tour Lab) and biochemists at University of Texas Health Science Center Houston (Tsai Lab). The group is testing a variety of engineered modifications of these versatile, non-toxic materials to address specific cell injury and death mechanisms including ferroptosis and interruption in electron transport and oxidative phosphorylation.
A major interest of ours is the role of diabetes in worsening outcome from stroke, a condition that affects minority and rural Texans disproportionally. With a range of research from molecular interactions to whole animal and clinical studies, the work in this lab is deeply translational, leveraging the group's clinical training and experience to insure that conclusions have direct relevance to the disease state, with the ultimate goal of facilitating the identification of new therapies for these major contributors to disability and mortality.
- Derry, P. J., Mandava, P., & Kent, T. A. (2019). Telemedicine in Prehospital Acute Stroke Care: An Expanding Infrastructure for Treatment and Research. Journal of the American Heart Association. 8(6), e012259.
- Alexandrov, A. V., Tsivgoulis, G., Köhrmann, M., Katsanos, A. H., Soinne, L., Barreto, A. D., ... Schellinger, P. D. (2019). Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke. Therapeutic Advances in Neurological Disorders. 12, 1756286419860652-175628641986065.
- Yang, X., Li, J., Fang, Y., Zhang, Z., Jin, D., Chen, X., ... Yu, F. (2018). Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms. Circulation Genomic and Precision Medicine. 11(7), e002099.
- Fabian, R. H., Derry, P. J., Rea, H. C., Dalmeida, W. V., Nilewski, L. G., Sikkema, W., ... Kent, T. A. (2018). Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats. FRONTIERS IN NEUROLOGY. 9(APR), 199.
- Ni, Y., Gu, W., Liu, Z., Zhu, Y., Rong, J., Kent, T. A., ... Zhang, H. (2018). RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway. NEUROSCIENCE. 371, 60-74.
- Martini, S. R., & Kent, T. A. (2016). Cerebrovascular disease. Neurology Secrets: Sixth Edition. (pp. 222-233). Elsevier.
- Martini, S. R., & Kent, T. A. (2013). Stroke and Transient Ischemic Attack. Cardiology Secrets: Fourth Edition. (pp. 433-443). Elsevier.
- Mandava, P., Krumpelman, C. S., Murthy, S. B., & Kent, T. A. (2012). A Critical Review of Stroke Trial Analytical Methodology: Outcome Measures, Study Design, and Correction for Imbalances. Translational Stroke Research. (pp. 833-861). Springer New York.
- Martini, S. R., & Kent, T. A. (2010). Stroke and TIA. Cardiology Secrets. (pp. 355-362). Elsevier.
- Derry, P. J., McHugh, E. A., Liopo, A. V., Tour, J. M., & Kent, T. A. (2019). A novel, injectable carbon nanoparticle demonstrates electron shuttling capabilities: a potential therapeutic \"nanozyme'' for mitochondrial protection in ischemic injury. Journal of Cerebral Blood Flow & Metabolism. 39, 367-367.
- Anderson, J. A., Kimmel, B., Xiaohui, T., Ovalle, A., Ifeorah, C., Gina, E., Nwangwa, D., & Kent, T. A. (2019). Mobile Health mHealth for Secondary Stroke Prevention is Feasible and Effective.. STROKE. 50,
- Mendoza, K., Cherian, L., Nilewski, L., Tour, J. M., Kent, T. A., & Robertson, C. S. (2018). A NEW CLASS OF CARBON ANTIOXIDANTS RESTORED CEREBRAL PERFUSION IN TRAUMATIC BRAIN INJURY COMPLICATED BY SYSTEMIC HYPOTENSION. Journal of Neurotrauma. 35(16), A5-A5.
- Mendoza, K., Cherian, L., Nilewski, L., Tour, J. M., Kent, T. A., & Robertson, C. S. (2018). A NEW CLASS OF CARBON ANTIOXIDANTS RESTORED CEREBRAL PERFUSION IN TRAUMATIC BRAIN INJURY COMPLICATED BY SYSTEMIC HYPOTENSION. Journal of Neurotrauma. 35(16), A21-A21.
- Kent, T., Perez-Polo, R., & Fabian, R. (2007). Functional uncoupling of perivascular nitric oxide production following neonatal hypoxia/ischemia. Journal of Cerebral Blood Flow & Metabolism. 27(SUPPL. 1),