Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis | Academic Article individual record
abstract

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

author list (cited authors)
Watanabe, J., Hattori, M., Berriman, M., Lehane, M. J., Hall, N., Solano, P., ... IGGI, ..
publication date
2014
published in
keywords
  • Molecular Sequence Data
  • Female
  • Molecular Sequence Annotation
  • Insect Vectors
  • Insect Proteins
  • Microbiota
  • Animals
  • International Glossina Genome Initiative
  • Reproduction
  • Sensation
  • Blood
  • Trypanosoma
  • Genome, Insect
  • Genes, Insect
  • Wolbachia
  • Salivary Glands
  • Symbiosis
  • Sequence Analysis, DNA
  • Trypanosomiasis, African
  • Tsetse Flies
  • Feeding Behavior
altmetric score

287.688

citation count

160