Comparative Molecular Life History of Spontaneous Canine and Human Gliomas. | Academic Article individual record
abstract

Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.

publication outlet

Cancer Cell

author list (cited authors)
Amin, S. B., Anderson, K. J., Boudreau, C. E., Martinez-Ledesma, E., Kocakavuk, E., Johnson, K. C., ... Verhaak, R.
publication date
2020
publisher
Elsevier bv Publisher
keywords
  • Canine Glioma
  • Pediatric Glioma
  • Tumor Suppressor Protein P53
  • Computational Biology
  • Comparative Oncology
  • Exome
  • Adult Glioma
  • Glioma
  • Brain Neoplasms
  • DNA Methylation
  • Animals
  • Humans
  • Mutation
  • Comparative Genomics
  • Isocitrate Dehydrogenase
  • Mutagenesis
  • Life History
  • Dogs
altmetric score

146.16

citation count

22

PubMed ID
32049048
identifier
419024SE
Digital Object Identifier (DOI)
start page
243
end page
257.e7
volume
37
issue
2