Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletionTargeting transcriptional addiction for the treatment of TSC | Academic Article individual record
authors
author list (cited authors)
Zarei, M., Du, H., Nassar, A. H., Yan, R. E., Giannikou, K., Johnson, S. H., ... Kwiatkowski, D. J.
publication date
2019
publisher
keywords
  • HEK293 Cells
  • Phenylenediamines
  • Female
  • Mechanistic Target Of Rapamycin Complex 1
  • Nf-e2-related Factor 2
  • Xenograft Model Antitumor Assays
  • Gene Expression Profiling
  • Gene Expression Regulation, Neoplastic
  • Tuberous Sclerosis
  • Neoplasms
  • Pyrimidines
  • Cells, Cultured
  • Cell Line, Tumor
  • Mice
  • Animals
  • Mutation
  • Cyclin-Dependent Kinases
  • Mice, Nude
  • Glutathione
  • Humans