Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane. | Academic Article individual record

The objective of this work was to analyze the antimicrobial and antibiofilm activities of bismuth lipophilic nanoparticles (BisBAL NPs) incorporated into chitosan-based membranes. Chitosan-based membranes were homogeneously embedded with BisBAL NPs, confirming the bismuth presence by scanning electron microscopy. The tensile strength of chitosan-based membrane alone or with BisBAL NPs showed similar results as elongation, suggesting that BisBAL NP addition did not affect membrane mechanical properties. Chitosan-based membranes complemented with 100 M of BisBAL NPs caused a complete inhibition of biofilm formation and a 90-98% growth inhibition of six different oral pathogens. Cytotoxicity studies revealed that 80% of human gingival fibroblasts were viable after a 24-h exposure to the chitosan-based membrane with 100 M of BisBAL NPs and collagen. Altogether, we conclude that the biological properties of chitosan-based membranes supplemented with BisBAL NPs could be a very interesting option for tissue regeneration.

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Dent Mater J

author list (cited authors)
Martnez-Martnez, M. A., Hernandez-Delgadillo, R., Abada, B. S., Pineda-Aguilar, N., Sols-Soto, J. M., Nakagoshi-Cepeda, M., ... Cabral-Romero, C.
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  • Chitosan-based Membranes
  • Cytotoxicity
  • Humans
  • Chitosan
  • Biofilm
  • Bismuth
  • Bismuth Lipophilic Nanoparticles
  • Anti-Bacterial Agents
  • Antimicrobial Activity
  • Nanoparticles
  • Anti-Infective Agents
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