Endosomal Escape and Cytosolic Penetration of Macromolecules Mediated by Synthetic Delivery Agents. | Academic Article individual record
abstract

Cell delivery reagents often exploit the endocytic pathway as a route of cell entry. Once endocytosed, these reagents must overcome endosomal entrapment to ensure the release of their macromolecular cargo into the cytosol of cells. In this review, we describe several examples of prototypical synthetic reagents that are capable of endosomal escape and examine their mechanisms of action, their efficiencies, and their effects on cells. Although these delivery systems are chemically distinct, some commonalities in how they interact with cellular membranes can be inferred. This, in turn, sheds some light on the process of endosomal escape, and may help guide the development and optimization of next-generation delivery tools.

author list (cited authors)
Brock, D. J., Kondow-McConaghy, H. M., Hager, E. C., & Pellois, J.
publication date
2019
published in
keywords
  • Cytosol
  • Drug Delivery Systems
  • Drug Carriers
  • Lipids
  • Nucleic Acids
  • Endosomes
  • Proteins
  • Humans
  • Endocytosis
  • Peptides
  • Animals
  • Polymers
citation count

4