Clindamycin and primaquine therapy for mild-to-moderate episodes of Pneumocystis carinii pneumonia in patients with AIDS: AIDS Clinical Trials Group 044. | Academic Article individual record
abstract

The objective of this prospective, noncomparative study was to assess the safety and efficacy of clindamycin and primaquine therapy for mild-to-moderate pneumocystis pneumonia (defined as a difference of < 40 mm Hg between the alveolar and the arterial oxygen determinations) in patients with AIDS. In the first part of the study, 22 patients were treated with iv clindamycin (900 mg every 8 hours) for the first 10 days, and then their therapy was switched to oral clindamycin (450 mg every 6 hours) for an additional 11 days. In the second part of the study, 38 patients were treated entirely with oral clindamycin (600 mg every 8 hours). All patients were treated with oral primaquine base (30 mg once daily). Fifty-five (92%) of 60 patients responded to the study treatment. Forty-six (77%) of 60 patients completed a full course of therapy. Of the nine patients with treatment-limiting toxic effects, four had only a mild rash. This study indicates that the combination of clindamycin and primaquine is an effective and well-tolerated therapy for mild-to-moderate pneumocystis pneumonia in patients with AIDS. Entirely oral therapy appears to be as effective as initial therapy with iv clindamycin.

authors
author list (cited authors)
Black, J. R., Feinberg, J., Murphy, R. L., Fass, R. J., Finkelstein, D., Akil, B., ... Plouffe, J. F.
publication date
1994
published in
keywords
  • Adolescent
  • Primaquine
  • Clindamycin
  • Pneumonia, Pneumocystis
  • Drug Administration Schedule
  • Humans
  • Administration, Oral
  • Drug Therapy, Combination
  • Middle Aged
  • AIDS-Related Opportunistic Infections
  • Acquired Immunodeficiency Syndrome
  • Prospective Studies
  • Adult
altmetric score

3.0

citation count

35