2017 by Taylor & Francis Group, LLC. The calcium ion serves as a versatile and universal second messenger to control a myriad of biological processes, including muscle contraction, neurotransmission, hormone secretion, immune cell activation, cell motility, and apoptosis [1-3]. The calcium release-activated calcium (CRAC) channel mediated by ORAI and stromal interaction molecule (STIM) constitutes one of the primary Ca2++ entry routes in non-excitable cells [4-6] (see Chapter 2). The CRAC channel is regarded as a prototypical example of store-operated Ca2++ entry (SOCE), in which the depletion of Ca2++ store in the endoplasmic reticulum (ER) induces calcium inux from the extracellular space. Over the past decade, tremendous progress has been made with respect to.
Calcium Entry Channels in Non-Excitable Cells